The Associations Between Oxytocin and Trauma in Humans: A Systematic Review.

Mariana Fortunata Donadon,Flávia De Lima Osório,Rocio Martin-Santos

doi:10.3389/fphar.2018.00154

Mariana Fortunata Donadon, Flávia De Lima Osório + Show 1 more

Open Access

https://doi.org/10.3389/fphar.2018.00154

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Abstract

Studies have shown that traumatic experiences may affect hormonal systems mediated by the hypothalamic-pituitary-adrenal (HPA) axis and the oxytocinergic system. This effect is the result of long-term impairments in hypothalamic structures and negative feedback mechanisms within the HPA axis, structures that mediate the response to stress. This deregulation reduces the production and release of cortisol and oxytocin (OXT), which may alter stress responses and lead to increased vulnerability to impairments from stressful experiences. The presence of gene polymorphisms might also have an impact on the vulnerability to psychopathology. We made a systematic review of articles dealing with the relationship between OXT and traumatic emotional experiences in humans. Thirty-five studies were reviewed and significant associations between experiences of emotional trauma (ET) and OXT were found. The main results showed that the presence of ET and post-traumatic stress disorder (PTSD) is strongly associated with reductions in endogenous OXT, and also that the acute effects of OXT administrations in individuals with ET tend to be anxiolytic only in less severe forms. In victims of recent traumatic experiences (RTE), OXT increased the re-experience of traumas and restored the function of different neural networks associated with fear control/extinction in PTSD patients. The results available also suggest that gene receptor polymorphisms may have a protective function in different outcomes after the experience of traumatic events. We conclude that the relationship between ET and OXT is multifaceted, complex, and mediated by contextual and individual factors. Directions for future studies are suggested considering the gaps in the available literature.

Highlights

Traumatic and stressful experiences throughout life, whether acute or chronic, may lead to changes in different bodily systems that increase the vulnerability to psychopathology (Meewisse et al, 2007; McQuaid et al, 2016)
Regarding the methodological quality evaluation, all of the studies included in this review had at least 64% of their essential items included in the STROBE, Transparent Reporting of Evaluations with Non-Randomized Designs (TREND) or CONSORT [experimental or randomized controlled trials (RCTs)]
Depending on their designs or objectives, the studies were divided into four distinct groups: (a) observational studies evaluating endogenous OXT levels; (b) experimental studies related to the reactivity of the oxytocinergic system; (c) RCTs of OXT administration and the experience of either emotional trauma (ET), recent traumatic experiences (RTE), or post-traumatic stress disorder (PTSD); and (d) observational studies investigating the effect of polymorphisms of the OXT receptor gene

Summary

Introduction

Traumatic and stressful experiences throughout life, whether acute or chronic, may lead to changes in different bodily systems that increase the vulnerability to psychopathology (Meewisse et al, 2007; McQuaid et al, 2016). Especially during the early stages of development, the HPA axis can be either hypoor hyperactived, with the possibility of excessive exposure to glucocorticoids and their deleterious effects These effects can persist throughout the lifespan because as the HPA axis may remain unstable, hypersensitive, or dysfunctional. This contributes to the weakening of the immune system, to increased vulnerability to different physical and mental illnesses, and to the inability to cope with subsequent stressful/traumatic events that may lead to exhaustion of the organism (Mirescu et al, 2004; Smith and Vale, 2006; Faravelli et al, 2012)

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