Abstract
ObjectiveTo identify the correlation between the level of at-admission fasting blood glucose (FBG) with poor outcomes in hospitalized patients suffering from severe fever with thrombocytopenia syndrome (SFTS).MethodsBetween April 1 and December 1, 2020, the list of hospitalized patients affected with SFTS infection was provided by the Infectious Disease Department at First Affiliated Hospital of Anhui Medical University, followed by the collection of information I.e., gender, age, diabetic history and the level of FBG on admission.ResultsIn this study, a total of 77 patients were included and were categorized into three groups (< 5.6, 5.6–6.9, and ≥ 7.0 mmol/l) on the basis of their glucose level in the blood. The obtained results revealed that among three groups considerable variations were observed in leukocytes, FBG, D-Dimer, aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α), fibrin degradation products (FDP), and interleukin (IL)-10 level. Correlation analysis indicated a linear negative correlation between PLT and FBG (r = − 0.28, P = 0.01), however, a linear positive correlation was observed between AST, IL10, D-Dimer, and FDP levels and FBG (P-value < 0.05). Multivariate statistical analysis results shown that there was significant difference between group comparison (F = 17.01, P < 0.001) and interaction between group and time (F = 8.48, P < 0.05); but there was no significant difference between time point comparison (F = 0.04, P = 0.96). With the prolongation of time, the changes of FBG were different between survivor group and non-survivor group. The FBG in survival group shown a downward trend; The non-survivor group shown an upward trend.ConclusionsElevated level of FBG has been correlated with hypercoagulability, inflammation, and lower PLT in SFTS patients. The measurement of FBG level can help in evaluating the inflammatory process, hypercoagulability, and prognosis of patients suffering from SFTS. FBG can predict the prognosis of SFTS. It is necessary to pay attention to the role of FBG in the process of treatment in patients with SFTS.
Highlights
Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease
SFTS has been caused by SFTS bunyavirus (SFTSV) and its transmission occurs through tick bites while sometimes, it can be transmitted through aerosol and blood transfer [4, 5]
Humans of all ages can be infected by SFTS but the people of old ages i.e., 50 ≥ are at higher risk due to compromised immune systems [6]
Summary
Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease. For the first time, the underlined infection was reported in China (2011) and the cases were appeared in South Korea and Japan [1,2,3].SFTS has been caused by SFTS bunyavirus (SFTSV) and its transmission occurs through tick bites while sometimes, it can be transmitted through aerosol and blood transfer [4, 5]. Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease. The underlined infection was reported in China (2011) and the cases were appeared in South Korea and Japan [1,2,3]. Humans of all ages can be infected by SFTS but the people of old ages i.e., 50 ≥ are at higher risk due to compromised immune systems [6]. The patients infected with SFTS may be asymptomatic or symptomatic with a common febrile illness that can lead. Zhang et al BMC Infectious Diseases (2021) 21:761 to hypovolemic shock and failure of multiple organs [7]. A mortality rate of 50% has been reported for SFTS [8]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
