Abstract
ABSTRACT Background Body composition is associated with bone mineral density (BMD), but the precise associations between body fat distribution and BMD remain unclear. The regional adipose tissue depots have different metabolic profiles. We hypothesized that they would have independent associations with BMD. Research Design and Methods We used data from 4,900 healthy individuals aged 30–50 years old from the Oxford Biobank to analyze associations between regional fat mass, lean mass and total BMD. Results Total lean mass was strongly positively associated with BMD. An increase in total BMD was observed with increasing mass of all the fat depots, as measured either by anthropometry or DXA, when accounting for lean mass. However, on adjustment for both total fat mass and lean mass, fat depot specific associations emerged. Increased android and visceral adipose tissue mass in men, and increased visceral adipose tissue mass in women, were associated with lower BMD. Conclusions Fat distribution alters the association between adiposity and BMD.
Highlights
Loss of bone mineral density (BMD) leading to osteoporosis or osteopenia causes significant morbidity [1]
Z-trans formed exposures were used in linear regression models to examine the association between total BMD, fat and lean mass and estimates are presented as standardized beta
The effect of regional fat depots on total, spine, pelvic, arm and leg BMD were examined using linear regression models adjusted for age and total lean mass, mutually adjusted for age, total lean and total fat mass and mutually adjusted for age, EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
Summary
Loss of bone mineral density (BMD) leading to osteoporosis or osteopenia causes significant morbidity [1]. These are complex disorders impacted on by aging [2], sex hormones [1], genetic predisposition [3], physical activity/lean body mass [2], and by adiposity through the concept of ‘sarcopenic obesity’ [2]. The regional adipose tissue depots have different metabolic profiles We hypothesized that they would have independent associations with BMD. Research Design and Methods: We used data from 4,900 healthy individuals aged 30–50 years old from the Oxford Biobank to analyze associations between regional fat mass, lean mass and total BMD. Conclusions: Fat distribution alters the association between adiposity and BMD
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