The Association Study of IL-23R Polymorphisms With Cerebral Palsy in Chinese Population.

Yangong Wang,Yiran Xu,Xiaoyang Wang,Lei Xia,Changlian Zhu,Changlian Zhu,Changlian Zhu,Juan Song,Dengna Zhu,Yu Su,Qinghe Xing,Qinghe Xing,Dan Bi,Chao Gao,Chao Gao,Xiaoli Zhang,Yimeng Qiao,Qing Shang,Qing Shang,Yangyi Fan

doi:10.3389/fnins.2020.590098

Abstract

Background: Cerebral palsy (CP) is a syndrome of non-progressive motor dysfunction caused by early brain development injury. Recent evidence has shown that immunological abnormalities are associated with an increased risk of CP.Methods: We recruited 782 children with CP as the case group and 770 healthy children as the control group. The association between IL-23R single nucleotide polymorphisms (SNPs; namely, rs10889657, rs6682925, rs1884444, rs17375018, rs1004819, rs11805303, and rs10889677) and CP was studied by using a case–control method and SHEsis online software. Subgroup analysis based on complications and clinical subtypes was also carried out.Results: There were differences in the allele and genotype frequencies between CP cases and controls at the rs11805303 and rs10889677 SNPs (Pallele = 0.014 and 0.048, respectively; Pgenotype = 0.023 and 0.008, respectively), and the difference in genotype frequency of rs10889677 remained significant after Bonferroni correction (Pgenotype = 0.048). Subgroup analysis revealed a more significant association of rs10889677 with CP accompanied by global developmental delay (Pgenotype = 0.024 after correction) and neonatal encephalopathy (Pgenotype = 0.024 after correction).Conclusion: The present results showed a significant association between IL-23R and CP, suggesting that IL-23R may play a potential role in CP pathogenesis.

Highlights

Cerebral palsy (CP) is a central motor disorder syndrome that manifests with abnormal muscle tension and motor function (Cheng et al, 2011; Wu et al, 2011)
The sample size utilized in the present study has >85% power to detect a significant association (α < 0.05) when using an effect size index of 0.1
The genotype distributions of rs17375018 among control subjects showed a significant deviation from Hardy– Weinberg equilibrium (HWE) (P = 0.011); we only analyzed the remaining six single nucleotide polymorphism (SNP), namely, rs10889657, rs6682925, rs1884444, rs1004819, rs11805303, and rs10889677

Summary

Introduction

Cerebral palsy (CP) is a central motor disorder syndrome that manifests with abnormal muscle tension and motor function (Cheng et al, 2011; Wu et al, 2011). Individuals with CP often exhibit sensory, perceptual, cognitive, communication, and behavioral disorders, as well as epilepsy and secondary musculoskeletal problems (Beliakoff and Sun, 2006). Perinatal medicine has IL23R and Cerebral Palsy developed rapidly in recent years, epidemiological studies have shown that the incidence of CP has remained stable at 2–3.5 children out of every 1,000 children (Pennington et al, 2013). Cerebral palsy (CP) is a syndrome of non-progressive motor dysfunction caused by early brain development injury. Recent evidence has shown that immunological abnormalities are associated with an increased risk of CP

Methods

Results

Conclusion