Abstract
Chronic hepatitis C is implicated in insulin resistance (IR) susceptibility. An X-ray repair cross-complementing group 1 gene (XRCC1) is proposed to be a candidate gene for a study of IR susceptibility. So, this study aims to investigate the possible association of the XRCC1 gene polymorphisms with the risk of IR related to chronic hepatitis C virus (HCV) infection in Egyptian patients. In a case-control study, a total of 210 subjects, including 140 chronic HCV patients (87 patients with IR and 53 without IR) and 70 healthy controls, were included. Two genetic polymorphisms (c.1254C > T and c.1517G > C) of the XRCC1 gene were genotyped via the PCR-restriction fragment length polymorphism (PCR-RFLP) technique. The result of the current study revealed that these two single nucleotide polymorphisms (SNPs) have statistically significant influences on susceptibility to IR in chronic HCV infected Egyptian patients. It could be concluded that c.1254C > T, the TT genotype, CT/CC carriers as well as c.1517G > C, the CC genotype and GC/GG carriers might be associated with increased IR susceptibility. Moreover, T-allele of c.1254C > T and the C-allele of c.1517G > C genetic variants might influence the susceptibility.
Highlights
Chronic hepatitis C virus (HCV) is the cause of the high proportion of cases of the chronic liver disease worldwide [1]
Chronic hepatitis C patients were further classified according to HOMA-insulin resistance (IR) into IR and non-IR groups
These results indicate that for c.1517G > C single nucleotide polymorphisms (SNPs), carrying mutant genotype (GC or CC,) or mutant C alleles may be associated with HCV infection but not related to developing IR in these patients (Table 2)
Summary
Chronic hepatitis C virus (HCV) is the cause of the high proportion of cases of the chronic liver disease worldwide [1]. It is reported in many cohort studies that patients suffering from chronic hepatitis C (CHC) infection have more risk to hepatic morbidity and mortality, mainly due to the progression to liver cirrhosis [2,3] with a higher possibility of the development of systemic extra-hepatic metabolic complications [1,4]. Kaddai et al [8] stated that HCV is associated with insulin resistance They reported alteration in glucose metabolism during the early stages of chronic hepatitis C. Reduction of viral load by the commonly used antiviral therapy is associated with marked improvement of glucose metabolism [10] and reduced insulin resistance state [11] in such patients
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