Abstract
BackgroundExisting inconclusive data on the relationship between vitamin D status and human glucose homeostasis suggests that other factors, such as adiposity, might influence this relationship. The present study aimed to investigate the association between 25-hydroxyvitamin D [25(OH)D] and fasting plasma glucose (FPG) in the context of different amounts of total body fat in a healthy community-based population in Bangkok, Thailand.MethodsThis cross-sectional study was a part of health survey of employees of the Electricity Generating Authority of Thailand. There were 1,990 healthy subjects (72.8% male) in this study. Total body fat was measured by bioelectrical impedance analysis. Total serum 25(OH)D, 25(OH)D3 and 25(OH)D2 were measured by LC-MS/MS.ResultsAge (r = 0.134, p < 0.001) and FPG (r = 0.089, p < 0.001) were positively correlated with 25(OH)D levels, while total body fat mass (r = -0.049, p = 0.03) were negatively correlated with 25(OH)D levels. 25(OH)D levels were higher in males than in females (65.0 ± 0.5 vs. 53.5 ± 0.5 nmol/L, p < 0.001). After controlling for age, gender and total fat mass, FPG was no longer correlated with 25(OH)D. However, when subjects were stratified according to fat-free mass tertiles and controlled for age and gender, there was a positive, although weak association between 25(OH)D levels and FPG (p = 0.01) in the lowest tertile.ConclusionsWe therefore speculate that adiposity might influence the relationship of vitamin D status and FPG.
Highlights
Existing inconclusive data on the relationship between vitamin D status and human glucose homeostasis suggests that other factors, such as adiposity, might influence this relationship
The aim of this study is to explore the relationship between 25(OH)D, a marker of vitamin D status, and fasting plasma glucose (FPG) in the context of different amounts of total body fat in a healthy community-based population in Bangkok, Thailand
A data comparison between males and females revealed that males were slightly older, had significantly higher body mass index (BMI), waist circumference (WC), fasting plasma glucose (FPG) and muscle mass, and significantly lower total body fat mass
Summary
Existing inconclusive data on the relationship between vitamin D status and human glucose homeostasis suggests that other factors, such as adiposity, might influence this relationship. The present study aimed to investigate the association between 25-hydroxyvitamin D [25(OH)D] and fasting plasma glucose (FPG) in the context of different amounts of total body fat in a healthy community-based population in Bangkok, Thailand. Several association studies have demonstrated a relationship between impaired vitamin D status and higher risk of prevalence as well as incidence of diabetes [7,8,9], these findings are not undisputed. We found in a recent study of subjects from the 4th Thai National Health Examination Survey (2,641 adults, aged 15–98) that low 25(OH)D3 but not 25(OH)D2 level was of total body fat in a healthy community-based population in Bangkok, Thailand. The secondary objective is to investigate the association between 25(OH)D and FPG in subgroups of subjects stratified by gender and age
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