Abstract
BackgroundThe aim of this study was to quantify the association of Val109Asp polymorphism of intelectin 1 (ITLN1) gene with the abdominal obesity (AO) in Kyrgyz population.MethodsPatients admitted to annual screening at a local outpatient facility were enrolled or this study. We genotyped 297 nonrelated adults of Kyrgyz ethnicity, of whom 127 were AO patients, including 46 men and 81 women with the mean age 53.2 ± 7.1 years, and 170 non-obese controls, including 61 men and 109 women with the mean age 52.0 ± 9.0 years. AO was defined as having waist circumferences ≥ 102 cm in men and ≥ 88 cm in women. We used PCR-RFLP method to define Val109Asp polymorphism of ITLN1 gene.ResultsAsp109Asp, Asp109Val and Val109Val genotypes were found in 48%, 40%, and 12% of AO patients respectively, and in 53%, 43%, and 4% of controls, whereas Val109Val homozygous genotype of ITLN1 gene Val109Asp polymorphic marker was significantly more prevalent in AO patients. In Kyrgyz population, Val109Val genotype of ITLN1 gene increased the risk of AO (odds ratio (OR) 3.12, 95% CI 1.23–7.90). Asp109Asp homozygous genotype, on opposite, was not associated with this condition (OR 0.82, 95% CI 0.53–1.30). Finally, the allelic variants of Val109Asp polymorphism of ITLN1 gene were not associated with AO.ConclusionSignificant increase in the frequency of Val109Val genotype of ITLN1 gene in AO patients may be indicative of some potential role of ITLN1 gene in molding genetic predisposition to AO in the Kyrgyz. This requires further elaboration in the future studies.
Highlights
The aim of this study was to quantify the association of Val109Asp polymorphism of intelectin 1 (ITLN1) gene with the abdominal obesity (AO) in Kyrgyz population
The aim of this study was to ascertain the risk of AO in Kyrgyz population associated with ITLN1 gene Val109Asp polymorphism
One hundred and seventy healthy subjects, of whom 61 were men and 109 women with the mean age 52.0 ± 9.0 with no known history of AO, cardiovascular diseases and with normal carbohydrate and lipid metabolism were controls. Both cases and controls in this study were subjected to a uniformed clinical examination, which included anamnesis, anthropometric tests (height, body mass, waist circumference (WC), hip circumference (HC)) with the subsequent calculation of body mass index (BMI), and blood pressure (BP) measurement (systolic (SBP) and diastolic (DBP)
Summary
The aim of this study was to quantify the association of Val109Asp polymorphism of intelectin 1 (ITLN1) gene with the abdominal obesity (AO) in Kyrgyz population. There is a trend towards growing prevalence of overweight and obese people in almost all populations in the twenty-first century [1]. Compared to 80–90s of the last century, the number of overweight people and those with obesity, including abdominal obesity rose almost two-fold, reaching the levels of 30.8%, 25.7% and 52.3% in Kyrgyz Republic [2]. Long-lasting misbalance between calorie intake and energy expenditure will result in the accumulation of visceral adipose tissue, resulting in excess bodyweight and even obesity [4]. Adipose tissue is known to synthesize series of adipocytokines, including leptin, adiponectin, resistin, visfatin, chemerin, vaspin, and apelin which all take part in the carbohydrates and lipids metabolism [5]. Omentin (Intelectin-1: ITLN1, OMIM: 609873) is one of recently discovered secretory proteins of visceral adipose
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