Abstract
The association of ultrafiltration with the outcomes of cardiopulmonary bypass surgery in adults with cardiovascular disease: The result of a systematic review and meta-analysis
Highlights
Previous studies have shown that ultrafiltration (UF) is associated with improved minor and major outcomes of cardiopulmonary bypass (CPB) by improving tissue perfusion as well as lowering the patient’s hematocrit and blood loss and reducing the mortality
Using UF in adult patients undergoing CPB is associated with reduced perioperative bleeding, red blood cell transfusion, and ICU length of stay
The use of UF was not associated with the reduction of major cardiovascular outcomes
Summary
Previous studies have shown that ultrafiltration (UF) is associated with improved minor and major outcomes of cardiopulmonary bypass (CPB) by improving tissue perfusion as well as lowering the patient’s hematocrit and blood loss and reducing the mortality. Cardiopulmonary bypass (CPB) contributes to hemodilution, coagulation abnormalities, activation of inflammatory mediators, and as a result end-organ dysfunction in cardiac surgery [1]. This hemodilution occurs due to the use of priming solution that fills the circuit before perfusion begins, it can be further exacerbated using cardioplegia solution. Once CPD is discontinues this hemodiluted blood remain in the extracorporeal circuit and is slowly transfused back to the patient during or after aortic decannulation This hemodilution after CBP can be reversed or reduced by Ultrafiltration (UF), in which cell-free fluid is removed from the circulation.
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