THE ASSOCIATION OF TRIGLYCERIDE-GLUCOSE INDEX AND RELATED PARAMETERS WITH HYPERTENSION AND CARDIOVASCULAR RISK

Abstract

Objective: Triglyceride-glucose index (TyG) was initially proposed as a reliable surrogate indicator for insulin resistance, which was later demonstrated to be associated with hypertension and CVD. The new parameters, TyG-BMI, TyG-WC, TyG-WHR and TyG-WHtR, which combine TyG and anthropometric indicators, were also reported to be related to hypertension and CVD. The study was designed to explore the association of TyG and related parameters with hypertension and cardiovascular risk. Design and method: A total of 16834 participants were enrolled in this study. Binary logistic regression analysis was used to explore the association between each parameter and the risk of hypertension and CVD across quartiles of TyG and related parameters. The receiver operating characteristic curve (ROC) was used to compare the diagnostic ability of TyG and its related parameters to identify people with hypertension and high cardiovascular risk. Results: The mean age of participants was 56.9 years, and 5776 (36.4%) were male. Compared with the lowest quartile groups of TyG and related parameters, the corresponding risks of hypertension in the highest quartile groups were significantly increased after adjustment. TyG-WC showed the highest diagnostic efficacy for hypertension (AUC: 0.665, 95% CI: 0.656 - 0.673) followed by TyG-WHtR (AUC: 0.664, 95% CI: 0.656 - 0.672), TyG-BMI (AUC: 0.658, 95% CI: 0.650 - 0.666), TyG-WHR (AUC: 0.655, 95% CI: 0.647 - 0.663) and TyG (AUC: 0.614, 95% CI: 0.605 - 0.622). Similarly, compared with the lowest quartile groups of TyG and related parameters, the corresponding risks of high cardiovascular risk in the highest quartile groups were also significantly increased. TyG-WC exhibited the strongest association with cardiovascular risk (OR: 8.167, 95% CI: 6.559 - 10.170). Furthermore, TyG-WHR showed the highest efficacy in distinguishing participants with high cardiovascular risk (AUC: 0.718, 95% CI: 0.710 - 0.726) followed by TyG-WC (AUC: 0.704, 95% CI: 0.695 - 0.712), TyG-WHtR (AUC: 0.674, 95% CI: 0.665 - 0.683), TyG-BMI (AUC: 0.639, 95% CI: 0.630 - 0.648) and TyG (AUC: 0.638, 95% CI: 0.629 - 0.647). Conclusions: The new parameters that combine TyG and anthropometric indicators have close and independent associations with hypertension and cardiovascular risk. Among them, TyG-WHR shows the highest efficacy in distinguishing participants with high cardiovascular risk, which may be helpful for the primary prevention of CVD.