The association of thiol/disulphide homeostasis with 6-month mortality in patients with acute st-elevation myocardial infarction

Abstract

Aim: Acute ST-elevation myocardial infarction (STMI) is significant determinant of mortality and long-term mortality rates has not changed significantly over the last two decades. Thiols are an important anti-oxidant mechanism in the body, and excessive reactive oxygen species oxidize the thiol into their disulphide forms. Hence, higher level of disulphide is regarded as an indicator of oxidative stress. In the present paper, we sought to investigate any probable relationship between thiol/disulphide homeostasis and 6-month all-cause mortality among STMI survivors.Material and Methods: 238 consecutive patients with STMI undergoing percutaneous coronary intervension were included. Blood samples for thiol/disulphide homeostasis were drawn on admission. Syntax I and II scores were calculated using the cineangiographic views and relevant patient demographics. Results: 6-month mortality occurred in 25 patients (mortality group), while 213 patients remained alive (non-mortality group). Total thiol, native thiol, disulphide, disulphide/total thiol , disulphide/native thiol and native thiol/total thiol were not different between the mortality and non-mortality groups (p>0.05). Syntax I and II scores were significantly greater in mortality group (26.11±8.06 vs 19.129.80, p=0.029 for Syntax I; 50.1314.59 vs 30.639.79, p<0.001 for Syntax II). Conclusion: Syntax II score, glomerular filtration rate (GFR) and white blood cell count (WBC) were found to predict 6-month mortality.