Abstract
// Wei Dai 1, * , Yu-Tuan Wu 2, * , Xin Li 2, * , Yan-Ling Shi 2, * , Lu Gan 3 , Hong-Yuan Li 2 , Guo-Sheng Ren 2 , Kai-Nan Wu 2 and Ling-Quan Kong 2 1 Department of Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China 2 Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China 3 Department of Oncology and Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China * These authors contributed equally to this work Correspondence to: Ling-Quan Kong, email: huihuikp@163.com Keywords: hepatitis B core antibody; hepatitis B virus; past infection; thyroid carcinoma; thyroid stimulating hormone Received: July 12, 2017 Accepted: December 05, 2017 Published: January 02, 2018 ABSTRACT Objective: To explore whether thyroid carcinoma is associated with the infection of hepatitis B virus. Results: Although there were no differences on the positive rates of Hepatitis B surface antigen and hepatitis B surface antibody in the thyroid carcinomas group (8.67% & 59.24%) and control group (8.86% & 58.21%, p > 0.05), the positive rate of hepatitis B core antibody in thyroid carcinomas group (55.71%) was significantly lower than that in the control group (63.28%, p = 0.0004). Through the logistic regression analysis, compared to the control group, the rate of hepatitis B core antibody seropositivity was lower in thyroid carcinomas group in whole cases ( Adjusted OR = 0.82, 95% CI 0.69–0.98, p = 0.0337). In addition, compared to the control group, a more interesting result was found that the adjusted OR value of hepatitis B core antibody seropositivity of male is lower than female in statistics ( Adjusted OR = 0.62, 95% CI 0.41–0.94, p = 0.0237; Adjusted OR = 0.89, 95% CI 0.72–1.08, p > 0.05, respectively). Conclusions: The rate of hepatitis B core antibody seropositivity in thyroid carcinoma patients is lower than that in controls and the past hepatitis B virus infection may be a weak protective factor for the development of thyroid carcinoma. Methods: In this study, the clinical data of 2134 patients with initially diagnosis of thyroid nodules while receiving surgery, with the reports of hepatitis B virus serological markers in single center from June 2010 to September 2015, were collected for comparative analysis. Of all there were 1050 (49.20%) cases of thyroid carcinomas group and 1084 (50.80%) noncancerous thyroid nodules group.
Highlights
Thyroid carcinoma (TC) is one of the most common endocrine malignancies
Compared with the estimated ratio of incidence of thyroid carcinoma collected from new cases of invasive cancer in Chinese female, which accounts for 3.8% [1], the number of it derived from developed countries is much higher [2]
1050 thyroid carcinoma cases in TC group, including 1005 papillary carcinoma (95.71%), 14 follicular carcinoma (1.33%), 7 anaplastic carcinoma (0.67%) and 24 others (2.29%), and 1084 noncancerous cases in control group were collected for comparative analysis (Table 1)
Summary
Compared with the estimated ratio of incidence of thyroid carcinoma collected from new cases of invasive cancer in Chinese female, which accounts for 3.8% [1], the number of it derived from developed countries is much higher [2]. All these data prove that prevention and treatment of thyroid carcinoma still can not be ignored. Some studies [6,7,8] by Western scholars indicate that thyroid carcinoma might be associated with HCV infection. Whether thyroid carcinoma is associated with HBV infection had remained unclear
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