The association of serum prolidase activity with developmental dysplasia of the hip

N. Soran,E. Işıkan,N. Aksoy,A. Taşkın,H. Çakır,O. Altindag,M. Soran

doi:10.1007/s00296-013-2672-9

N. Soran, E. Işıkan + Show 5 more

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https://doi.org/10.1007/s00296-013-2672-9

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Abstract

The purpose of this study was to evaluate serum prolidase activity in patients with developmental dysplasia of the hip (DDH). Prolidase enzyme activity was measured spectrophotometrically to pointing out the collagen metabolism. The prolidase activity in patients with DDH was significantly higher than that in the control group (p = 0.002). Furthermore, there was positive correlation between prolidase activity and dysplasia level. Increased serum prolidase activity may have played a role in the presence of DDH. We therefore hypothesized that the increased prolidase activity related to collagen turnover may be associated with etiopathogenesis and/or the progression of the disease.

Highlights

Developmental dysplasia of the hip (DDH) is a common congenital abnormality that affects the developing hip joint of the newborn
Anatomical abnormalities of the hip joint arose from a deviation in normal hip to the developmental hip disorders including partial or complete displacement of the femoral head from acetabulum during infantile growth period [2]
The mean value of prolidase enzyme activity level was 575.11 ± 22.66 and 519.24 ± 9.99 IU in patients and Fasting blood samples were withdrawn and their sera were separated with centrifugation at 3,000 rpm for 10 min, and the serum samples were stored at -80 °C until analysis

Summary

Introduction

Developmental dysplasia of the hip (DDH) is a common congenital abnormality that affects the developing hip joint of the newborn. DDH is a comprehensive term used to describe a spectrum of anatomical abnormalities of the hip that may be congenital or may develop during infancy and/ or childhood. DDH refers to dysplasia of the acetabulum (deficient development) or instability of the hip, such that the femoral head can be partially or completely moved out of the acetabulum [1]. The etiology of hip dysplasia is not clear, but this condition does appear to be related to a number of different factors. Female sex, being the first-born child and breech positioning are all associated with an increased prevalence of DDH. Other factors possibly related to DDH include intrauterine positioning and sex, and some of these are interrelated

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