Abstract
Objective: To explore the close relationship between respiratory syncytial virus (RSV) infection and acute attack of childhood asthma. Methods: A computer-based search of database from Pumbed, CNKI, Wanfang, Baidu Scholar, Chongqing VIP, GeenMedica was performed to screen the articles about respiratory syncytial virus infection and childhood asthma. Then the literatures were screened out by the selection criteria. The RevMan5.3 software was used to test the heterogeneity and effect values of each study, analyze the sensitivity and publication bias of the literature, and draw on Meta forest plot and Funnel plot. Results: 5 articles conformed to the selection criteria. There were totally 881 cases in the case group, 826 cases in the control group. The results of heterogeneity test showed no heterogeneity between each study (P > 0.05). The fixed-effects model showed the 6.68 (5.06 - 8.82), (Z = 13.38, P < 0.00001). Conclusion: The infection rate of respiratory syncytial virus in children with acute asthma attack is higher than that in remission period. Respiratory syncytial virus infection rate can be used as an indicator of the severity of asthma in children.
Highlights
There are reports that respiratory syncytial virus is closely related to airway hyperresponsiveness, asthma attack and recurrent wheezing
Some studies believe that the mechanism of recurrent wheezing caused by respiratory syncytial virus (RSV) is through stimulating the body to produce IgE, which can mediate type I allergy and cause asthma attack [14] [15], and through destroying cilia and columnar epithelial cells on the surface of the airway, increasing permeability, causing airway hyperreactivity, enhancing airway sensitivity to allergens [16], decreasing the excitability of respiratory β receptor or destroying cholinergic receptor, increasing the excitability of vagus nerve reaction in the airway [17]
This study explored that there is a close relationship between respiratory syncytial virus infection and acute attack of asthma in children
Summary
Respiratory virus infection is the main cause of bronchial asthma. The study shows that the proportion of asthma in children is up to 90% [2] Viral infection is both a source of infection and an allergen in the body, and there is an inflammatory reaction that can cause asthma exacerbation [3]. Respiratory syncytial virus, human rhinovirus, corona virus, influenza virus and adenovirus can cause asthma attacks in children. The study found that the incidence of recurrent wheezing after RSV infection was higher than 60%, and about 30% children were diagnosed with asthma at the age of 7.5, the high risk of asthma still existed at the age of 13 [7]. The aim of this article is to study the respiratory syncytial virus secretion during acute infection period and remission of bronchial asthma in children asthma. This article analyzed the changes of RSV infection rate in acute infection and remission stage, to further learn the clinical significance of RSV in childhood asthma
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
