The association of polymorphisms in miRNAs with nonsmall cell lung cancer in a Han Chinese population

Abstract

BackgroundMicroRNAs (miRNAs) have been demonstrated to play important roles in cancer progression. Recently, studies have revealed that polymorphisms in miRNAs might be associated with cancer susceptibility.Materials and methodsIn the current study, we investigated the associations of single nucleotide polymorphisms (SNPs) in miRNAs (rs11134527 in pri-miR-218-2, rs74693964 in pri-miR-145, rs6062251 in pri-miR-133a-2, and rs4705343 in pri-miR-143) with nonsmall cell lung cancer (NSCLC) in a Han population from Yunnan Province, Southwest China using a binary logistic regression analysis. A total of 452 patients with NSCLC and 452 healthy individuals were recruited for polymorphism genotyping using the TaqMan assay.ResultsOur results showed that the allelic frequencies of rs11134527 and rs4705343 were significantly different between the NSCLC and control groups (P=0.025 and 0.029). Additionally, the genotypic frequencies of rs11134527 were significantly different between the NSCLC and control groups (P=0.045). The mode of inheritance analysis showed that genotypes A/G+G/G of rs11134527 were associated with a lower risk of NSCLC under the dominant model (OR=0.69; 95% CI: 0.51–0.94). In addition, genotypes 2C/C+C/T of rs4705343 were associated with an increased risk of NSCLC under the log-additive model (OR=1.25; 95% CI: 1.01–1.53). However, there was no significant difference in the other SNPs between the NSCLC and control groups (P>0.05). Moreover, the association analysis of these SNPs between adenocarcinoma and squamous cell carcinoma (SCC) showed that allele A of rs11134527 was associated with SCC (OR=0.65; 95% CI: 0.48–0.88).ConclusionOur results indicated that the A allele of rs11134527 might be a risk factor (OR=1.24; 95% CI: 1.03–1.50) and that the T allele of rs4705343 might be a protective factor (OR=0.80; 95% CI: 0.66–0.98) for NSCLC in a Han Chinese population.