Abstract
How single nucleotide polymorphisms in long non-coding RNAs are involved in cancer susceptibility remains poorly understood. We hypothesized that polymerase II polypeptide E (POLR2E) rs3787016 polymorphism, identified in a genome-wide association study of prostate cancer, might be a common genetic risk factor for cancer risk. To address this issue, we here conducted a case–control study to investigate the association of POLR2E rs3787016 polymorphism with risk of liver and lung cancer (including 800 normal controls, 480 liver cancer patients, and 550 lung cancer patients), followed by a meta-analysis. The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing. Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink. Moreover, the meta-analysis demonstrated that rs3787016 was associated with overall cancer risk and prostate cancer risk. Collectively, the POLR2E rs3787016 polymorphism may be a valuable biomarker for cancer predisposition.
Highlights
Liver and lung cancers are commonly diagnosed cancers with high mortality rate in China [1,2]
It is emergent to identify certain inherited genetic variants associated with susceptibility to liver and lung cancer, which would be in favor of making early diagnosis and risk prediction
Aberrant expression of lncRNAs has been identified in many cancer types, including liver and lung cancer, suggesting that lncRNAs might be involved in tumorigenesis and tumor progression [5]
Summary
Liver and lung cancers are commonly diagnosed cancers with high mortality rate in China [1,2]. Great progress has been made in diagnosis and treatment of cancers over the past decade, the 5-year overall survival rates of lung and liver cancer patients remain low [3]. It is emergent to identify certain inherited genetic variants associated with susceptibility to liver and lung cancer, which would be in favor of making early diagnosis and risk prediction. Aberrant expression of lncRNAs has been identified in many cancer types, including liver and lung cancer, suggesting that lncRNAs might be involved in tumorigenesis and tumor progression [5]. Single nucleotide polymorphism (SNP), which can affect the expression and function of genes, has been reported to be associated with susceptibility to many kinds of human complex diseases including cancer [6]
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