Abstract
BackgroundNumerous studies have shown that plasma fibrinogen was linked to esophageal cancer (EC) risk. However, the clinical significance of plasma fibrinogen in EC patients remain unclear and need to be further clarified.ResultsA total of 2865 patients with EC from 11 published studies were included in this meta-analysis. The prognostic and clinical relevance of plasma fibrinogen were evaluated in EC patients. Statistical significance of the pooled hazard ratio (HR) was found for overall survival (OS), disease free survival (DFS) and recurrence-free survival (RFS) in EC. Subgroup analyses for OS were also performed to confirm the prognostic value of plasma fibrinogen. Additionally, the overall results indicated that elevated plasma fibrinogen was significantly associated with tumor invasion, lymph node metastasis (LNM) and clinical stage.Materials and MethodsA comprehensive literature retrieval was performed in PubMed, Embase, Cochrane database, Web of science and Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases to identify relevant studies published prior to April 15, 2017.ConclusionsElevated plasma fibrinogen could be served as a promising biomarker for predicting a poor prognosis and unfavorable clinicopathologic features for EC.
Highlights
Esophageal cancer (EC), as one of the most aggressive cancers, has been the fifth leading cause of cancer-related deaths in China, the eighth most common cancer worldwide [1, 2]
The prognostic and clinical relevance of plasma fibrinogen were evaluated in esophageal cancer (EC) patients
Subgroup analyses for overall survival (OS) were performed to confirm the prognostic value of plasma fibrinogen
Summary
Esophageal cancer (EC), as one of the most aggressive cancers, has been the fifth leading cause of cancer-related deaths in China, the eighth most common cancer worldwide [1, 2]. Numerous studies have reported that fibrinogen level in plasma was upregulated in several types of cancers and related to cancer progression and prognosis [9,10,11,12,13,14]. Wang and Takeuchi [16, 17] demonstrated that plasma fibrinogen was a valuable predictor for disease progression and prognosis in ESCC. Li et al [18] reported that there was no significant association between preoperative plasma fibrinogen level and prognosis of ESCC. The prognosis value of plasma fibrinogen in EC was still unclear without methodical analysis. Numerous studies have shown that plasma fibrinogen was linked to esophageal cancer (EC) risk. The clinical significance of plasma fibrinogen in EC patients remain unclear and need to be further clarified
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