The Association of Paraoxonase-1 Polymorphism with Carotid Artery Stenosis among Elderly Chinese Population

Jianyun Sun,Xianhui Ding,Qian Yang,Zhiming Zhou,Ke Yang,Long Wang,Taofeng Zhou

doi:10.1155/2020/3084120

Abstract

Elderly population is in high risk of carotid atherosclerosis and artery stenosis (CAS). It has been proved that PON1 polymorphism is associated with low-density lipoprotein (LDL) oxidation, which plays an important role in artery atherosclerosis. CAS is an important cause of ischemic stroke. This study is aimed at investigating the association of PON1 (rs662) polymorphism with the risk of CAS among elderly Chinese population. Consecutive elderly patients with CAS were enrolled into the study. Genotyping for PON1 (rs662) polymorphism was performed on all participants. There were 310 CAS patients in this study, with 88 symptomatic CAS and 222 asymptomatic CAS. G allele had a frequency of 59.66% in symptomatic CAS (sCAS); and A allele had an incidence of 36.93% in asymptomatic CAS (aCAS) (P < 0.05). In all CAS patients with and without symptom, no associations were found in any genotype comparison. However, among aCAS subjects, based on GA phenotype, the odds ratio (OR) of the mutant GG with stenosis severity was 0.20 (P = 0.01). The OR of GG+GA mutation was 0.28 for moderate/severe severity, compared with GA type (P = 0.03). This study indicates that PON1 (rs662) polymorphism is not associated with the presence of symptom among CAS patients. Moreover, PON1 (rs662) polymorphism correlates with stenosis severity among aCAS.

Highlights

Carotid artery stenosis (CAS) is a well-defined factor of stroke risk [1], which accounts for approximately 10-15% of population with ischemic stroke [2]
We showed the characteristics of symptomatic CAS (sCAS) and asymptomatic CAS (aCAS) based on the severity of artery stenosis (Table 2)
High level of Low-density lipoprotein (LDL) is a major cause for this pathology; the oxidation of LDL enhances the inflammatory status in the vascular system [22]

Summary

Introduction

Carotid artery stenosis (CAS) is a well-defined factor of stroke risk [1], which accounts for approximately 10-15% of population with ischemic stroke [2]. PON1 is a calcium-dependent esterase involved in the activity of HDL, which is capable of hydrolyzing a wide range of subtracts [8]. It combines with arylesterase and catalyses the hydrolysis of organophosphate esters, aromatic carboxylic acid esters, and carbamates [9]. PON1 is proved to be associated with the hydrolysis of oxidized phospholipids in oxidized LDL [10]. It inhibits the oxidation of LDL and prevents the subsequent atherosclerosis change in the carotid artery [11]. The associations of PON1 polymorphism with CAS risk remain unknown

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Conclusion