The association of P-terminal force value and increased risk for ischemic stroke among admitted patients in a tertiary hospital: a retrospective case-control study

Abstract

Abstract Funding Acknowledgements Type of funding sources: None. Background Cerebrovascular disease is the second leading cause of mortality in the Philippines, with prevalence of 0.9 to 2.6%.³ However, recent researches show that left atrial abnormality, even without atrial fibrillation, increases risk for ischemic stroke. Purpose This study aims to determine the association of P-terminal force value in V1 (PTFV1) and ischemic stroke. Secondary objectives are to elucidate the relationships of PTFV1 and dilated left atrium (LA), and dilated LA and ischemic stroke. Methods This is a retrospective case-control study which included adult Asian patients managed as first-time ischemic stroke, with an age-, gender- and co-morbidity-matched control group. A total of 290 patients were evaluated. Binary logistic regression was used in the analysis of the primary outcome, while independent T-test and chi-square test were utilized for the secondary outcomes. Results PTFV1 and ischemic stroke had a statistically significant positive association. Every 1 unit change of PTFV1 confers 1.7% increased risk for ischemic stroke. Furthermore, a higher PTFV1 was significantly correlated with dilated LA. However, there was no significant association between dilated LA and ischemic stroke. Conclusion PTFV1 confers an easier way to diagnose patients with left atrial abnormality, and stratify those with increased risk for ischemic stroke.