The association of Overhydration Status with Depression and Health-related Quality of Life in Peritoneal Dialysis Patients

Abstract

Aim This study was to determine the association of overhydration (OH) status with depression and health-related quality of life (HRQOL) in peritoneal dialysis (PD) patients. Methods A multicenter study was conducted in 628 PD patients. Body composition monitor, Beck׳s Depression Inventory (BDI) and Kidney Disease Quality of Life short form, version 1.3 were used to evaluate OH status, depression and HRQOL, respectively. Patients were divided into two groups according to the OH status; −2L≤OH≤2L group and OH>2L group. Results The BDI score did not differ between the two groups. However, the OH>2L group showed significantly lower physical, mental, and kidney-disease related quality of life (QOL) scores compared with the −2L≤OH≤2L group. The OH>2L group showed significantly lower scores in all of the physical QOL subcategories (physical functioning, role-physical, bodily pain, and general health) than the −2L≤OH≤2L group. Among the mental QOL subcategory, scores of social function were significantly lower in the OH>2L group than the −2L≤OH≤2L group. Among the kidney disease-related QOL subcategory, scores of effect of kidney disease, burden of kidney disease, and cognitive function were significantly lower in the OH>2L group than the −2L≤OH≤2L group. In a multivariate analysis, OH status was not an independent predictor for BDI score and physical and mental QOL scores. However, OH status independently predicted kidney disease-related QOL score (β=−2.354, p=0.012). Conclusion In conclusion, OH negatively affects HRQOL in PD patients. Intensive efforts to control fluid overload may improve HRQOL of PD patients.