The association of nutrition with interdialytic weight gain and depressive disorder in hemodialysis patients

Abstract

Malnutrition was reported to occur in 23–76% and known as an important predictor of increased mortality in maintenance hemodialysis (HD) patients. This study was performed to evaluate the association of nutrition with interdialytic weight gain (IDWG) and depression in HD patients. Sixty-five HD patients for at least 3 months were enrolled. We investigated malnutrition by OSND (Objective score of Nutrition on dialysis) score and depressive disorder by Montgomery depression rating scale and Hamilton depression rating scale. We compared the clinical and biochemical profiles according to the presence of malnutrition. Mean age of the patients was 55.7±12.6 years and patients with diabetes accounted 55.4%. Mean duration of HD was 36.2±32.0 (4–129) months. Depressive disorder was diagnosed in 21 (32.3%), Malnutrition (OSND score 1 kg/day) in 40 (61.5%) out of the 65 HD patients. Patients with malnutrition had lower incidence of large IDWG (45.8% vs 70.7%, p=0.046) and depression (19.5% vs 54.1%, p=0.004) than those without. BMI (21.2±3.0 vs 23.4±3.0 kg/m2 ,p=0.006), TSF (triceps skin fold thickness, 8.8±4.2 vs 15.0±6.2 mm, p Fig. Multivariate analysis of risk factors for malnutrition in chronic HD patients (n=65) (R2= 0.285). In conclusion, we suggest that the depressive disorder may be considered in HD patients at the time of the assessment of nutritional status in maintenance HD patients. In addition, it is hard to use large IDWG as an indicator of nutrition in maintenance HD patients.