The Association of Metabolic Brain MRI, Amyloid PET, and Clinical Factors: A Study of Alzheimer's Disease and Normal Controls From the Open Access Series of Imaging Studies Dataset.

Abstract

Although brain activities in Alzheimer's disease (AD) might be evaluated MRI and PET, the relationships between brain temperature (BT), the index of diffusivity along the perivascular space (ALPS index), and amyloid deposition in the cerebral cortex are still unclear. To investigate the relationship between metabolic imaging measurements and clinical information in patients with AD and normal controls (NCs). Retrospective analysis of a prospective dataset. 58 participants (78.3 ± 6.8 years; 30 female): 29 AD patients and 29 age- and sex-matched NCs from the Open Access Series of Imaging Studies dataset. 3T; T1-weighted magnetization-prepared rapid gradient-echo, diffusion tensor imaging with 64 directions, and dynamic 18 F-florbetapir PET. Imaging metrics were compared between AD and NCs. These included BT calculated by the diffusivity of the lateral ventricles, ALPS index that reflects the glymphatic system, the mean standardized uptake value ratio (SUVR) of amyloid PET in the cerebral cortex and clinical information, such as age, sex, and MMSE. Pearson's or Spearman's correlation and multiple linear regression analyses. P values <0.05 were defined as statistically significant. Significant positive correlations were found between BT and ALPS index (r = 0.44 for NCs), while significant negative correlations were found between age and ALPS index (rs = -0.43 for AD and - 0.47 for NCs). The SUVR of amyloid PET was not significantly associated with BT (P = 0.81 for AD and 0.21 for NCs) or ALPS index (P = 0.10 for AD and 0.52 for NCs). In the multiple regression analysis, age was significantly associated with BT, while age, sex, and presence of AD were significantly associated with the ALPS index. Impairment of the glymphatic system measured using MRI was associated with lower BT and aging. 3 TECHNICAL EFFICACY STAGE: 1.