Abstract
PurposeA variety of studies have observed that the single nucleotide polymorphisms (SNPs) matrix metalloproteinase-9 (MMP-9) gene may be associated with the risk of gastric cancer(GC), and a cytosine (C) to thymine (T) mutation at the -1562 site of the MMP-9 gene promoter is reported to be closely related to the susceptibility. However, because of the conflicting results of these studies, we undertook a systematic meta-analysis to assess the association between the SNPs and the risk of gastric cancer.Materials and MethodsA computerised literature search was conducted within the databases of PubMed, EMBASE, and ISI Web of Knowledge for studies on the genetic association of MMP-9-1562C/T and gastric cancer published from 2004 to 2015. The pooled odds ratio (OR) and 95% confidence intervals (CI) were estimated for each genotype using the dominant, recessive, co-dominant, and allelic models of the matrix metalloproteinase 9.ResultsOur analysis indicated a significant association of MMP-9-1562C/T with gastric cancer (dominant model [CT+TT/CC]: OR = 1.121, 95% CI = 0.965–1.304; recessive model [CC+CT/TT]: OR = 1.663, 95% CI = 1.148–2.408; co-dominant model [TT/CC]: OR = 1.666, 95% CI = 1.127–2.461; [CT/CC]: OR = 1.078, 95% CI = 0.923–1.259; allelic model [T/C]: OR = 1.150, 95% CI =1.014–1.304).ConclusionsOur meta-analysis results demonstrated that MMP-9-1562C/T promoter polymorphisms increase the risk of developing gastric cancer.
Highlights
Gastric cancer is one of the most common cancers worldwide and one of the most common causes of cancer-related deaths in the developed world
A variety of studies have observed that the single nucleotide polymorphisms (SNPs) matrix metalloproteinase-9 (MMP-9) gene may be associated with the risk of gastric cancer(GC), and a cytosine (C) to thymine (T) mutation at the -1562 site of the Matrix metalloproteinases (MMPs)-9 gene promoter is reported to be closely related to the susceptibility
Our analysis indicated a significant association of MMP-9-1562C/T with gastric cancer
Summary
Gastric cancer is one of the most common cancers worldwide and one of the most common causes of cancer-related deaths in the developed world (fourth for men and fifth for women). Multiple genetic and environmental factors may contribute to the incidence of gastric cancer. When the interaction of these factors leads to a series of mutations in the related genes of the body, abnormal cells may begin hyperplasia and a tumour forms. Matrix metalloproteinases (MMPs) are a class of proteolytic enzymes that are closely related to tumorigenesis, invasion and metastasis. Depending on their substrate specificity and domain structure, MMPs can be divided into five divergent groups: collagenases, gelatinases, stromelysins, matrilysins and membrane-type MMPs [2]. Studies have found a cytosine (C) to thymine (T) mutation at the -1562 site of the MMP-9 gene promoter, which may affect the expression level of the MMP-9 gene
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
