The Association of Lipoprotein-a Levels, Neutrophil Lymphocyte Ratio and Hypertension with the Clinical Severity Scale Measured by NIHSS Scale in Patients with Acute Thrombotic Stroke

Abstract

Background: The correlation between levels of Lipoprotein-a, Neutrophil Lymphocyte Ratio andhypertension with clinical severity scale remains a controversial issue.Objective: To determine the correlation of levels of Lipoprotein-a, Neutrophil Lymphocyte Ratio andhypertension with the severity scale measured by NIHSS scale in patients with acute thrombotic stroke.Method: Lipoprotein-a levels, Neutrophil Lymphocyte ratio, blood pressure in patients with acute thromboticstroke were measured and clinical severity scale was assessed by NIHSS scale. The levels of lipoprotein-awere grouped into normal and high levels of lipoprotein-a, Lymphocyte Neutrophil Ratios were groupedinto low and high and hypertension were grouped into stage 1 and 2. The data was analyzed using logisticregression.Results: There were 40 patients consisting of 29 (72.50%) male patients and 11 (27.50%) female patients.The demographic data included gender, age, LDL level, random blood sugar level, diabetes mellitus statusand smoking status which were all homogeneous in both groups of lipoprotein-a, Neutrophil Lymphocyteratio and hypertension stage. In the logistic regression analysis, the lipoprotein-a and neutrophil lymphocyteratio were correlated with clinical severity scale (p = 0.018, RO 0.122 (CI 95% 0.022-0.696) vs p = 0.041,RO 0.068 (95% CI 0.005-0.895) while hypertension stage was not correlated with clinical severity scale (p= 0.97, RO 1.02 (95% CI 0.28-3.80).Conclusion: The levels of lipoprotein-a and lymphocyte neutrophil ratio were related to the clinical severitymeasured by NIHSS scale but not with hypertension