The association of Interleukin-10 and Interleukin-13 polymorphisms with susceptibility to vitiligo: A study in Iranian patients

Abstract

Vitiligo is an autoimmune disease with non-pigmented and pale white patches in skin. Different studies showed that cytokines play a role in the onset of vitiligo symptoms. The aim of the present study was to investigate the association of IL-10 and IL-13 polymorphisms with susceptibility to vitiligo. With this aim, DNA was extracted from peripheral blood of 90 patients with vitiligo and 90 healthy individuals. Then, the genotype of IL-10 (rs1800896 T > C and rs1800872 T > G) and IL-13 (rs2069756 T > C and rs1295685 G > A) polymorphisms was determined by PCR-RFLP. The results of statistical analysis indicated that the heterozygote genotype of rs1800872 as well as rs2069756 significantly decreased the susceptibility to vitiligo (p < 0.05). However, no association was observed between rs1800896 and rs1295685 polymorphisms and the risk of vitiligo (p > 0.05). Among the patients, the heterozygote genotype of rs1800872 polymorphism showed to be associated with increased risk of Acrofacial phenotype development (p < 0.05). The obtained results suggested that heterozygote genotype of rs1800872 and rs2069756 polymorphisms play a protective role against development of vitiligo (p < 0.05). However, the heterozygote genotype of rs1800872 could be stated as a susceptible factor for onset of Acrofacial phenotype in patients with vitiligo.