Abstract
ObjectiveTo investigate the association between IL7R rs6897932 and multiple sclerosis (MS) in southern Chinese people.MethodsIn total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping.ResultsWith genetic models, we can observe that the additive model, the dominant model, and the recessive model of IL7R rs6897932 were significantly associated with MS [additive model: p=0.032; dominant model (adjusted): p<0.001, OR=3.61 (95% CI 2.25–5.83); recessive model (adjusted): p<0.001, OR=6.80 (95% CI 3.49–13.89)].ConclusionOur results suggest that IL7R rs6897932 is associated with MS in a southern Chinese population. More and larger MS studies to explore the genetic risk factors of MS are warranted.
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