The Association of Gut Microbiota With Idiopathic Central Precocious Puberty in Girls.

Guoqing Dong,Wenkui Dai,Sitang Gong,Miao Huang,Peihui Liu,Xiyan Lu,Zhenyu Yang,Jianxu Li,Yongmei Zeng,Jiyong Zhang,Yinhu Li,Dongfang Li,Ximing Xu,Xin Feng,Minghui Qiu,Xiaoping Luo

doi:10.3389/fendo.2019.00941

Abstract

Idiopathic central precocious puberty (ICPP) is a relatively common condition in preadolescent girls, and its pathogenesis remains to be uncovered. A variety of studies have highlighted the association of gut microbiota (GM) with endocrine diseases, such as obesity, which is commonly associated with ICPP. However, the relationship between GM and ICPP remains unexplored. Feces samples were collected from 25 girls with ICPP (ICPP group) and 23 healthy girls (Control group). We applied 16S rDNA sequencing to compare the GM between two groups. The ICPP group had higher GM diversity and was enriched for several GM species, including Ruminococcus gnavus, Ruminococcus callidus, Ruminococcus bromii, Roseburia inulinivorans, Coprococcus eutactus, Clostridium leptum, and Clostridium lactatifermentans, which are known to be associated with obesity and are related to the production of short-chain fatty acids. Additionally, 36 candidate GM biomarkers for patients with ICPP screening were identified with high accuracy (AUC = 0.95, 95% CI 0.88 to 1). We observed that the GM of the ICPP group was enriched for the microbial functions of cell motility, signal transduction, and environmental adaptation. Positive correlations were also detected between Fusobacterium and follicle-stimulating hormone, and Gemmiger and luteinizing hormone. This study documents relationships between GM and ICPP, and the implication of these findings remains to be determined.

Highlights

Central precocious puberty (CPP) results from earlier than expected maturation of the hypothalamic-pituitary-gonadal (HPG) axis during preadolescence [1]
590 Operational Taxonomic Units (OTUs) were generated, and 173 ± 38.926 OTUs were yielded for each patients with Idiopathic central precocious puberty (ICPP), while 109 ± 33.131 OTUs were obtained for each healthy girl
The gut genera that were enriched in the ICPP group, such as Ruminococcus Gemmiger, Oscillibacter, and Clostridium XlVb, are similar to those that are associated with obesity

Summary

Introduction

Central precocious puberty (CPP) results from earlier than expected maturation of the hypothalamic-pituitary-gonadal (HPG) axis during preadolescence [1]. CPP is a relatively common pediatric endocrine condition, observed in 1 in 5,000 to 1 in 10,000 children [2]. When CPP occurs in a patient without an identifiable predisposing condition, it is called idiopathic CPP (ICPP) [3]. Girls are more likely to have ICPP than boys (5 to 10 times higher prevalence in girls than in boys) [4]. ICPP triggers signs of sexual maturation earlier than typically expected, with the appearance of. Gut Microbiota of Precocious Girls secondary sex characteristics before 8 and 9 years of age in girls and boys, respectively [5]. The pathogenesis of ICPP remains to be explored

Methods

Results

Conclusion