Abstract
Objective: The present study was conducted for exploring the influence of fibroblast growth factor 2 receptor (FGFR2) gene polymorphisms on osteoporosis occurrence risk in the Chinese population.Methods: Polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) was conducted for the genotyping of polymorphism in 145 osteoporosis patients and 123 controls. The status of Hardy–Weinberg equilibrium was detected in the control group. Genotype and allele frequency comparison of polymorphism between the two groups was performed by χ2 test, odds ratio (OR) with 95% confidence interval (95% CI) was used for the result expression about the association of FGFR2 polymorphisms with osteoporosis. Furthermore, the results were adjusted by clinical features via logistic regression analysis.Results: AA genotype and A allele of rs2420946 were significantly associated with the increased risk of osteoporosis development adjusted by clinical features (OR = 2.238, 95% CI = 1.055–4.746; OR = 1.482, 95% CI = 1.042–2.019). Similarly, CC genotype and C allele frequencies of rs1219648 were detected the significant difference between the case and control groups (P<0.01); moreover, it was still significant by the adjustion of clinical features, which indicated that rs1219648 was significantly associated with the risk of osteoporosis occurrence (OR = 2.900, 95% CI = 1.341–6.271; OR = 1.602, 95% CI = 1.126–2.279). Haplotype T-A-C-T also obviously increased the occurrence risk of osteoporosis (OR = 1.844, 95% CI = 1.180–2.884). Besides, the significant interaction of FGFR2 polymorphisms with drinking status in osteoporosis was also found (P<0.05), especially rs2981579.Conclusion: FGFR2 rs2420946 and rs1219648 polymorphisms may be the risk factor of osteoporosis in Chinese population. Furthermore, the interaction of FGFR2 polymorphisms with drinking may play an important role in osteoporosis etiology.
Highlights
Osteoporosis is a common systemic bone disease in elderly characterized by the progressive bone mass loss and the degeneration of bone microarchitecture, which results in the decreased bone strength and increased risk of fracture [1,2]
We explored the influence of fibroblast growth factor 2 receptor (FGFR2) on osteoporosis via genetic variants based on the Chinese Han population and four most common single nucleotide polymorphisms (SNPs) in FGFR2 were included in the present study
Osteoporosis patients were diagnosed by specialist physicians through measuring the bone mineral density (BMD) of lumbar vertebra and bilateral femoral proximal femur, tibia using dual X-ray absorption-metry (DXA), according to the diagnosis criteria of World Health Organization (WHO) [16], that was, the T-score of BMD measured by DXA was less than or equal to −2.5 S.D
Summary
Osteoporosis is a common systemic bone disease in elderly characterized by the progressive bone mass loss and the degeneration of bone microarchitecture, which results in the decreased bone strength and increased risk of fracture [1,2]. The prevalence of osteoporosis increases with the age [3] and is increasing annually. Its incidence rate is 14.94% in 2008 and the percentage reach to 27.96% during 2012–2015 in China [4]. The occurrence of osteoporosis threatens or damages the physical health and life quality of patients, causing enormous economic losses [5]. Revealing the pathogenesis of osteoporosis is an urgent problem so as to prevent and treat it. Osteoporosis is a multifactorial disease influenced by genetic and environmental factors [6,7], of which genetic factors
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
