Abstract
BackgroundAge-related hearing impairment (ARHI) is a major disability among the elder population. Chronic inflammation is an important factor in the development of ARHI. Interleukin-1 (IL-1) plays a key role in inflammation and may be associated with ARHI. The aim of this study is to analyze the associations of single nucleotide polymorphisms (SNPs) of IL-1 receptor genes with ARHI in an elderly population in Taiwan.MethodParticipants ≥65 years of age were recruited for audiometric tests and genetic analyses. The bilateral pure-tone average (PTA) of high-tone hearing levels was calculated for ARHI evaluation. The associations of SNPs of the IL-1 receptor type 1 gene (IL1R1) (rs3917225 and rs2234650) and type 2 gene (IL1R2) (rs4141134 and rs2071008) with ARHI were analyzed in 182 ARHI-susceptible (case) and 176 ARHI-resistant (control) participants.ResultsThe G allele of IL1R1 rs3917225 showed a decreased risk of ARHI after adjustments for sex, age, and noise exposure. The GG genotype of IL1R1 rs3917225 in all hereditary models and the TT genotype of IL1R2 rs2071008 in the recessive model also showed decreased risks of ARHI after adjustments.ConclusionThese findings suggest that IL1R1 and IL1R2 polymorphisms may contribute to the decreased risk of ARHI in the elderly population.
Highlights
Age-related hearing impairment (ARHI), or presbycusis, is one of the major disabilities among the elderly population
Experimental inner ear inflammation studies have shown the in vivo production of tumor necrosis factor-α (TNF-α), interleukin-1 β (IL-1β), and
Some authors found that the transplantation of the thymus into mice may alter the expression of IL-1 receptor type 2 on CD4+ T cells and recover the hearing in mice with ARHI [10]
Summary
Age-related hearing impairment (ARHI), or presbycusis, is one of the major disabilities among the elderly population. Interleukin-1 (IL-1) plays a key role in inflammation and autoimmune diseases by activating the expression of genes associated with the innate and adaptive immune response [8]. Alternations in the expression of IL-1 receptor type 1 and type 2 may be associated with the development of ARHI. Age-related hearing impairment (ARHI) is a major disability among the elder population. The aim of this study is to analyze the associations of single nucleotide polymorphisms (SNPs) of IL-1 receptor genes with ARHI in an elderly population in Taiwan. The associations of SNPs of the IL-1 receptor type 1 gene (IL1R1) (rs3917225 and rs2234650) and type 2 gene (IL1R2) (rs4141134 and rs2071008) with ARHI were analyzed in 182 ARHI-susceptible (case) and 176 ARHI-resistant (control) participants
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