Abstract
BackgroundThe association of platelet endothelial cell adhesion molecule 1 (PECAM1), hypoxia-inducible factor 1 subunit alpha (HIF1A), and KIAA1462 in myocardial infarction (MI) was investigated. The study included 401 Han Chinese MI patients and 409 controls. Three tag single-nucleotide polymorphisms (SNPs)—PECAM1 rs1867624, HIF1A rs2057482, and KIAA1462 rs3739998—were selected. SNP genotyping was performed by an improved multiplex ligation detection reaction assay. A systematic review and meta-analysis of studies including 3314 cases and 2687 controls on the association of 5 HIF1A SNPs and the overall risk of MI or coronary artery disease (CAD) was performed.ResultsThe rs1867624 variants were associated with high TG concentrations (p = 0.040) and the rs2057482 variants were associated with decreased HDL-C in MI patients compared with the control group (p = 0.003). Rs2057482 SNP interacted with age to influence TC levels. The SNP of rs3739998 interacted with sex and hypertension to modulate CRE and TG levels, respectively (p < 3.04E-5-0.002). No association between the three SNPs and susceptibility to MI was found (p > 0.05 for all). In the meta-analysis of HIF1A, the rs11549465 C > T and rs10873142 T > C polymorphisms, but not rs2057482, rs11549467, and rs41508050, were correlated with overall MI or CAD risk.ConclusionsTaken together, this study provides additional evidence that genetic variation of the PECAM1 rs1867624 and HIF1A rs2057482 can mediate lipid levels in MI patients.
Highlights
The association of platelet endothelial cell adhesion molecule 1 (PECAM1), hypoxia-inducible factor 1 subunit alpha (HIF1A), and KIAA1462 in myocardial infarction (MI) was investigated
The recent targeted gene array derived from earlier genome-wide association studies (GWAS) results and performed meta-analysis of results have made huge advances in identifying genetic components of coronary artery disease (CAD) risk with 15 mainly novel risk loci, including single-nucleotide polymorphisms (SNPs) in or near genes involved in major lipids, blood pressure, and vascular smooth muscle cell differentiation [5]
0.040) and the rs2057482 variants were associated with decreased HDL-C in MI patients compared with the control group (p = 0.003)
Summary
The association of platelet endothelial cell adhesion molecule 1 (PECAM1), hypoxia-inducible factor 1 subunit alpha (HIF1A), and KIAA1462 in myocardial infarction (MI) was investigated. The recent targeted gene array derived from earlier genome-wide association studies (GWAS) results and performed meta-analysis of results have made huge advances in identifying genetic components of CAD risk with 15 mainly novel risk loci, including single-nucleotide polymorphisms (SNPs) in or near genes involved in major lipids, blood pressure, and vascular smooth muscle cell differentiation [5]. Several of these have been validated by large-scale association studies [6, 7].
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