Abstract

The aim of the study was to study the associations of electrophysiological signs of metabolic disorders the myocardium (ECG phenomenon TV1>TV6 and components of the ECG of the of left ventricular hypertrophy phenomenon) with some lipid and non-lipid risk factors in an urban population of 25–44 years. Material and methods. A population survey of a random sample of the population aged 25–44 years (1439 people, 656 men, 783 women) in Novosibirsk was conducted. Blood concentrations of total cholesterol, high (HDL-C) and low density lipoprotein cholesterol (LDL-C), and triglycerides were measured. Systolic and diastolic blood pressure, body mass index, waist circumference, presence of arterial hypertension, smoking status were evaluated. The following ECG markers were analyzed: ECG phenomenon TV1>TV6 (the amplitude of T in V1 exceeds the amplitude of T in V6), components of the ECG of the of left ventricular hypertrophy phenomenon. Results. ECG phenomenon TV1>TV6 was detected in 0.8 % of people (1.4 % of men, 0.2 % of women). In the general population among people with ECG phenomenon TV1>TV6, persons with triglyceride levels >150 mg/dl, with an increased body mass index/waist circumference, with arterial hypertension are 3.0, 2.0, 2.3 and 3.5 times more, respectively, than among people without ECG phenomenon TV1>TV6. Among men with ECG phenomenon TV1>TV6, persons with elevated triglyceride levels, with an increased body mass index/waist circumference, with arterial hypertension are 2.2, 1.5, 2.5 and 2.8 times more, respectively, than among men without ECG phenomenon TV1>TV6. The components of the ECG of the of left ventricular hypertrophy phenomenon were found in 1.4 % of people (2.1 % of men, 0.9 % of women). In the general population, among people with elevated triglyceride levels, with arterial hypertension, as well as in smokers – individuals with signs of left ventricular hypertrophy are 2.3, 2.1 and 1.7 times more, respectively, than without them. Among men with elevated blood levels of LDL-C, non-HDL-C, as well as smokers-individuals with components of the ECG of the of left ventricular hypertrophy phenomenon are 1.4, 1.4 and 1.6 times more, respectively. Conclusions . ECG phenomenon TV1>TV6 and components of the ECG of the of left ventricular hypertrophy phenomenon are associated with lipid and non-lipid risk factors for cardiovascular diseases, which indicates a potentiating effect of metabolic disorders in the body not only on the development of risk factors for cardiovascular diseases, but also metabolic disorders of the myocardium.

Highlights

  • Цель исследования – изучить ассоциации электрофизиологических признаков метаболических нарушений миокарда (ЭКГ феномен TV1>TV6 и компоненты ЭКГ феномена гипертрофии левого желудочка (ГЛЖ)) с некоторыми липидными и нелипидными факторами риска в городской популяции 25–44 лет

  • II receptor blockers combined with calcium channel blockers on metabolic

  • Among men with elevated blood levels of LDL-C, non-HDL-C, as well as smokers-individuals with components of the ECG of the of left ventricular hypertrophy phenomenon are 1.4, 1.4 and 1.6 times more, respectively

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Summary

МАТЕРИАЛ И МЕТОДЫ

На базе НИИ терапии и профилактической медицины – филиала Федерального государственного бюджетного научного учреждения «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук» (НИИТПМ – филиал ИЦиГ СО РАН) в течение 2013–2017 гг. проведено одномоментное популяционное обследование случайной выборки жителей одного из типичных районов г. Для построения выборки использована база данных территориального Фонда обязательного медицинского страхования по Новосибирской области, из которой с помощью генератора случайных чисел отобрано 2500 мужчин и женщин в возрасте 25–44 лет. В скрининг-центре НИИТПМ – филиал ИЦиГ СО РАН обследовано 1515 человек, от всех получено информированное согласие на обследование и обработку персональных данных. В результате использования методов сравнения выборок установлено, что в возрасте 25–44 лет мужчин с ЭКГ синдромом TV1>TV6 статистически значимо больше, чем женщин (соответственно 1,4 и 0,2 %, p = 0,014). Мы провели анализ связи ЭКГ феномена TV1>TV6 с липидными и нелипидными факторами риска ССЗ в популяции 25–44 лет в целом, а также у мужчин и женщин Таблица 1 Связь ЭКГ феномена TV1>TV6 с факторами риска ССЗ в популяции 25–44 лет г.

Есть феномена феномен феномена феномен феномена феномен
Нет компонентов ЭКГ феномена
Findings
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