Abstract
Background:Vitamin D and Calcium have a possible protective impact versus rectal neoplasm. Vitamin D, an important nutrient, is vital to regulate the absorption of calcium and bone mineralization; nevertheless, in a case-control study in Iran, we investigated the relationship among the dietary intake of vitamin D and calcium with the hazard of rectal neoplasm. Methods:363 subjects (162 cases and 201 controls) participated in the case- control Study from March 2017 to November 2018. Dietary intake of Calcium and Vitamin D was calculated using a 148-items food-frequency questionnaire.Results:Since altering the strong confounding agents, the multivariate risk proportion within the dietary vitamin D intake was OR=0.2, 95%CI 0.1-0.5, P-value <0.001 among cases. There was no association in case of calcium and rectal cancer. Conclusions:Taken together, a possible reduction in the hazard of rectal neoplasm with dietary intake of Vitamin D within Iranian patients was observed.
Highlights
Colorectal cancer (CRC) is a typical neoplasm, which widely recognized as a main agent of mortality in the worldwide (Ferlay et al, 2013)
Vitamin D, an important nutrient, is vital to regulate the absorption of calcium and bone mineralization; in a case-control study in Iran, we investigated the relationship among the dietary intake of vitamin D and calcium with the hazard of rectal neoplasm
Contributors who has presented a detect of heart diseases, diabetes, all types of cancers and other serious diseases, consumption of calcium/vitamin D supplements or regular non-steroidal anti-inflammatory drugs (NSAID) (n = 11) were excluded
Summary
Colorectal cancer (CRC) is a typical neoplasm, which widely recognized as a main agent of mortality in the worldwide (Ferlay et al, 2013). Several mechanisms might clarify the possibly defensive impacts of calcium and vitamin D versus CRC, involving the joint of secondary bile acids and fatty acids that practice as a motive for colon and intestinal lumen epithelial cells (Harris et al, 2004; Feldman et al, 2014). Vitamin D and Calcium have a possible protective impact versus rectal neoplasm. Vitamin D, an important nutrient, is vital to regulate the absorption of calcium and bone mineralization; in a case-control study in Iran, we investigated the relationship among the dietary intake of vitamin D and calcium with the hazard of rectal neoplasm. Conclusions: Taken together, a possible reduction in the hazard of rectal neoplasm with dietary intake of Vitamin D within Iranian patients was observed
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
