Abstract
BackgroundEvidence of possible beneficial effects of dietary diabetes risk reduction score (DDRRS) on reducing the risk of various chronic diseases such as metabolic syndrome (MetS) are limited. This is a prospective, population-based cohort study, which aimed to investigate the relationship of the DDRRS and its components with MetS incident in Iranian adults.MethodsIndividuals without MetS (n=3561) were recruited from participants of the Tehran Lipid and Glucose Study (2009-2011) and followed for a mean of 6.01 years. A validated food frequency questionnaire was used to determine the DDRRS using based on eight components, including higher intakes of cereal fiber, nuts, coffee, and polyunsaturated: saturated fat ratio and lower intakes of red or processed meats, sugar-sweetened beverages, trans fatty acids, and low glycemic index. We used the multivariable logistic regression analysis to determine the odds ratio (ORs) and 95 % confidence interval (CI) of MetS across the tertiles of DDRRS.ResultsThe mean (SD) age of individuals was 38.1(12.6) years at baseline. Median (25-75 interquartile range) DDRRS for all participants was 20(18-22). During the study follow-up, 682(19.1 %) new cases of MetS were reported. Based on the age and sex-adjusted model, participants in highest tertile of DDRRS had lower risk of MetS in compared with the lowest one (OR=0.64;95 %CI:0.52-0.79, P for trend=0.001). In the multivariable adjusted model, after adjustment for all possible confounding variables, the risk of MetS is decreased across tertiles of DDRRS (OR=0.60;95 %CI:0.48-0.75, P for trend=0.001). Also, higher scores of some DDRRS components including red and processed meat, sugar sweetened beverages, and coffee were related to decreased incidence of MetS.ConclusionsThe results of this study revealed that greater adherence to DDRRS can be associated with decreased risk of MetS in Iranian adult.
Highlights
Evidence of possible beneficial effects of dietary diabetes risk reduction score (DDRRS) on reducing the risk of various chronic diseases such as metabolic syndrome (MetS) are limited
Metabolic syndrome (MetS) is a clustering of metabolic risk factors, including central obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDLC), elevated blood pressure, and hyperglycemia [1], which can increase the risk of type 2 diabetes, cardiovascular disease (CVD), cancer, and all-cause mortality [2, 3]
Subjects This study was performed in the framework of the Tehran Lipid and Glucose Study (TLGS), a populationbased cohort study conducted to assess the risk factors for non-communicable diseases among a representative urban population of Tehran, including 15,005 participants aged ≥3 years [21]
Summary
Evidence of possible beneficial effects of dietary diabetes risk reduction score (DDRRS) on reducing the risk of various chronic diseases such as metabolic syndrome (MetS) are limited. This is a prospective, population-based cohort study, which aimed to investigate the relationship of the DDRRS and its components with MetS incident in Iranian adults. Investigating the association between nutritional factors in the form of a single food pattern score and risk of chronic diseases, such as MetS can provide more accurate and applicable findings
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