Abstract
BackgroundBody-mass index (BMI) and depressed mood are both positively associated with pain and activity limitations in knee osteoarthritis (OA), and are interrelated. The aims of the present study were: 1) to assess whether BMI and depressed mood are independently associated with knee pain and activity limitations; and 2) to compare the relative contributions of BMI and depressed mood to knee pain and activity limitations.MethodsA cross-sectional study in 294 patients with clinical knee OA. Regression analyses were performed with knee pain or activity limitations (self-reported and performance-based) as dependent variables, and BMI and depressed mood as independent variables. All analyses were adjusted for age, gender, marital status, education level, radiographic OA and comorbidity. Dominance analyses were performed to examine the relative contributions of BMI and depressed mood to knee pain and activity limitations.ResultsBMI and depressed mood were positively and independently associated with knee pain and activity limitations. BMI and depressed mood explained small parts (3.0% and 2.3%, respectively) of variance in knee pain. BMI explained a substantial part of variance in both self-reported (9.8%) and performance-based (20.4%) activity limitations, while depressed mood explained a small part of variance (3.1% in self-reported and 2.6% in performance-based activity limitations).ConclusionsIn patients with knee OA both BMI and depressed mood seem to be independently associated with knee pain and activity limitations. The contribution of BMI to activity limitations is most substantial, thereby offering a relevant target for interventions.
Highlights
Body-mass index (BMI) and depressed mood are both positively associated with pain and activity limitations in knee osteoarthritis (OA), and are interrelated
Overweight and depressed mood are more common in knee osteoarthritis (OA) than in the general population [1,2,3], and are both positively associated with pain and activity limitations [4,5,6,7,8,9,10,11,12,13]
The aims of the present study were: 1) to assess whether body-mass index (BMI) and depressed mood are independently associated with knee pain and activity limitations in patients with knee OA; and 2) to compare the relative contributions of BMI and depressed mood to knee pain and activity limitations
Summary
Body-mass index (BMI) and depressed mood are both positively associated with pain and activity limitations in knee osteoarthritis (OA), and are interrelated. Two studies that examined a broad set of determinants of pain and activity limitations in patients with knee OA found that BMI and depressed mood were independently associated with pain and activity limitations [12,17]. The five studies described above were not primarily aimed at examining the interrelations between BMI, depressed mood, pain and activity limitations. They did not examine the relative contributions of BMI and depressed mood to pain and activity limitations. There is a need to examine these interrelations more thoroughly
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