The association of alcohol consumption with patient survival after organophosphate poisoning: a multicenter retrospective study.

Abstract

Organophosphate (OP) intoxication remains a serious worldwide health concern, and many patients with acute OP intoxication have also consumed alcohol. Therefore, we evaluated the association of blood alcohol concentration (BAC) with mortality among patients with OP intoxication. We retrospectively reviewed records from 135 patients who were admitted to an emergency department (ED) for OP intoxication between January 2000 and December 2012. Factors that were associated with patient survival were identified via receiver operating characteristic curve, multiple logistic regression, and Kaplan-Meier survival analyses. Among 135 patients with acute OP poisoning, 112 patients survived (overall mortality rate: 17%). The non-survivors also exhibited a significantly higher BAC, compared to the survivors [non-survivors: 192mg/dL, interquartile range (IQR) 97-263mg/dL vs. survivors: 80mg/dL, IQR 0-166.75mg/dL; p<0.001]. A BAC cut-off value of 173mg/dL provided an area under the curve of 0.744 [95% confidence interval (CI) 0.661-0.815], a sensitivity of 65.2%, and a specificity of 81.2%. A BAC of>173mg/dL was associated with a significantly increased risk of 6-month mortality in the multiple logistic regression model (odds ratio 4.92, 95% CI 1.45-16.67, p=0.001). The Cox proportional hazard model revealed that a BAC of>173mg/dL provided a hazard ratio of 3.07 (95% CI 1.19-7.96, p=0.021). A BAC of>173mg/dL is a risk factor for mortality among patients with OP intoxication.