Abstract
BackgroundThe association between vitamin D levels and non-alcoholic fatty liver disease (NAFLD) has been increasingly determined in recent researches. The aim of this study was to determine the association between vitamin D levels, measured as serum 25-hydroxy vitamin D (25(OH)D) and NAFLD. Serum 25(OH)D was prospectively determined in 80 patients. Of them, 40 subjects had NAFLD, whereas 40 subjects served as healthy control. Vitamin D deficiency was defined as serum 25(OH)D level < 20 ng/ml. Receiver operating characteristic (ROC) and regression analysis methods were used in our analysis.ResultsAbout 70% of patients with NAFLD had vitamin D deficiency, but only 35% in the control group had. The mean serum 25 (OH)D was significantly lower in patients with NAFLD than the healthy control group (16.13 ± 10.23 versus 27.35 ± 10.58 ng/mL; P < 0.001). ROC curve analysis revealed that serum 25(OH)D level of less than 11.2 ng/ml increases the risk of NAFLD with 45% sensitivity and 97.5% specificity (Serum 25(OH)D level ≤ 18.1 ng/ml in males and ≤ 9.4 ng/ml in females increase the risk of NAFLD). Multivariate regression analysis showed that vitamin D deficiency, high age, and high BMI were associated with a significant high risk of NAFLD.ConclusionNAFLD patients have low serum vitamin D concentrations, suggesting that vitamin D may have a role in the development of NAFLD. Future studies are recommended to determine the important therapeutic implications of vitamin D for the prophylaxis or the treatment of NAFLD.
Highlights
The association between vitamin D levels and non-alcoholic fatty liver disease (NAFLD) has been increasingly determined in recent researches
Recent studies show that the progression of NAFLD is not always linear, it is not who is more likely to transform into more advanced stages [4], considered as the hepatic manifestation of NAFLD in most cases associated with type 2 diabetes and dyslipidemia [5]
Eighty subjects participated in the present study, of whom 40 subjects had NAFLD, whereas 40 subjects served as healthy control
Summary
The association between vitamin D levels and non-alcoholic fatty liver disease (NAFLD) has been increasingly determined in recent researches. The aim of this study was to determine the association between vitamin D levels, measured as serum 25-hydroxy vitamin D (25(OH)D) and NAFLD. Non-alcoholic fatty liver disease (NAFLD) is a clinicohistopathological entity with histological features that occurs in patients with little or no history of alcohol consumption. NAFLD is classified into non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Recent studies show that the progression of NAFLD is not always linear, it is not who is more likely to transform into more advanced stages [4], considered as the hepatic manifestation of NAFLD in most cases associated with type 2 diabetes and dyslipidemia [5]
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