Abstract
The association between vitamin D levels and necrotizing enterocolitis in preterm neonates
Highlights
Necrotizing enterocolitis (NEC) is a frequent gastrointestinal inflammatory disease among preterm infants and characterized by bowel wall necrosis
No significant associations were observed between NEC with maternal and neonatal levels of vitamin D status
Our results showed a significant positive correlation between maternal and neonatal vitamin D status
Summary
Necrotizing enterocolitis (NEC) is a frequent gastrointestinal inflammatory disease among preterm infants and characterized by bowel wall necrosis. The incidence of NEC and its related mortality rate in preterm infants with very low birth weight were reported 5–10% and 15-30%, respectively [1,2,3]. Preterm birth, intestinal immaturity, hemodynamic instability, intestinal microbial ecology, non-breastfeeding nutritions, microbial abnormalities in the digestive system, and exaggerated responses of the immune system are some of them [4,5,6]. Some investigations have focused on the influences of 1, 25-Dihydroxy vitamin D3 on inflammatory bowel diseases. Inhibition of T helper cells proliferation, a decrease of interleukin, interferon-g and tumor necrosis factor productions were demonstrated by vitamin D. Vitamin D receptors (VDR) are expressed in both colonic mucosa and immune cells [7,8,9]
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