Abstract
A B S T R A C TBackground: vitamin D has an important influence on the host’s immune system bymodulating both innate and adaptive immunity and regulating the inflammatorycascade. Vitamin D deficiency may be related with reduced immunomodulation,specifically in preventing the occurrence of chronic tonsillitis. Objective: to identify theassociation between vitamin D deficiency with chronic tonsillitis in pediatric patients.Methods: the search was conducted with advanced searching on PubMed® andCochrane® according to the clinical question. The screening of title and abstract usinginclusion and exclusion criteria, double filter, and reading full text led to six usefularticles. The selected studies were critically appraised for validity, importance, andapplicability. Results: three original articles were eligible for this evidence-based casereport. All studies were considered to have good validity. All three studies reported anincreased risk of chronic tonsillitis with the vitamin D deficiency and/or insufficiency.Conclusion: Vitamin D deficiency may be associated with the increased risk of chronicor recurrent tonsillitis in children.
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