Abstract
BackgroundThe triglyceride-glucose (TyG) index is a reliable indicator of insulin resistance. We aimed to investigate the TyG index in relation to cardio-cerebrovascular diseases (CCVDs and mortality.MethodsThis retrospective study included 114,603 subjects. The TyG index was categorized into four quartiles by sex: Q1, <8.249 and <8.063; Q2, 8.249‒<8.614 and 8.063‒<8.403; Q3, 8.614‒< 8.998 and 8.403‒<8.752; and Q4, ≥8.998 and ≥8.752, in men and women, respectively. To calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the primary outcomes (CCVDs and all-cause mortality) and secondary outcomes (cardiovascular diseases [CVDs], cerebrovascular diseases [CbVDs], CCVD-related deaths, or all-cause deaths), Cox proportional hazards regression models were adopted.ResultsCompared to Q1, the HRs (95% CIs) for the primary outcomes of Q2, Q3, and Q4 were 1.062 (0.981‒1.150), 1.110 (1.024−1.204), and 1.151 (1.058−1.252) in men and 1.099 (0.986−1.226), 1.046 (0.938−1.166), and 1.063 (0.954−1.184) in women, respectively, after adjusted for age, smoking status, drinking status, physical activity, body mass index, systolic blood pressure, low-density lipoprotein cholesterol, economic status, and anti-hypertensive medications. Fully adjusted HRs (95% CIs) for CVDs of Q2, Q3, and Q4 were 1.114 (0.969−1.282), 1.185 (1.031−1.363), and 1.232 (1.068−1.422) in men and 1.238 (1.017−1.508), 1.183 (0.971−1.440), and 1.238 (1.018−1.505) in women, respectively. The adjusted HRs (95% CIs) for ischemic CbVDs of Q2, Q3, and Q4 were 1.005 (0.850−1.187), 1.225 (1.041−1.441), and 1.232 (1.039−1.460) in men and 1.040 (0.821−1.316), 1.226 (0.981−1.532), and 1.312 (1.054−1.634) in women, respectively, while the TyG index was negatively associated with hemorrhagic CbVDs in women but not in men. The TyG index was not significantly associated with CCVD-related death or all-cause death in either sex.ConclusionsElevated TyG index was positively associated with the primary outcomes (CCVDs and all-cause mortality) in men and predicted higher risk of CVDs and ischemic CbVDs in both sexes.
Highlights
Cardiovascular diseases (CVDs) and cerebrovascular diseases (CbVDs), which include coronary heart disease, peripheral arterial disease, and deep vein thrombosis in addition to other diseases of the heart and brain, are the leading cause of death worldwide [1]
Elevated TyG index was positively associated with the primary outcomes (CCVDs and allcause mortality) in men and predicted higher risk of CVDs and ischemic CbVDs in both sexes
This study aimed to examine whether the TyG index was associated with primary outcomes (CCVDs and all-cause mortality) in Korean adults, based on the Korean National Health Insurance Service (NHIS)-National Health Screening (HEALS) cohort
Summary
Cardiovascular diseases (CVDs) and cerebrovascular diseases (CbVDs), which include coronary heart disease, peripheral arterial disease, and deep vein thrombosis in addition to other diseases of the heart and brain, are the leading cause of death worldwide [1]. CVDs and CbVDs are the second and fourth most common causes of death in Korea, respectively [2]. These cardio-cerebrovascular diseases (CCVDs) are a large burden on public health and a considerable number can be avoided by early detection and active management of their risk factors such as a healthy lifestyle. The triglycerideglucose (TyG) index is a novel reliable indicator to detect the early phase of insulin resistance and type 2 diabetes [8–10]. Several studies have reported that the TyG index was superior to HOMA-IR in predicting type 2 diabetes in the Korean population [10]. The triglyceride-glucose (TyG) index is a reliable indicator of insulin resistance. We aimed to investigate the TyG index in relation to cardio-cerebrovascular diseases
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
