The association between triglyceride glucose index and depression: data from NHANES 2005\u20132018

Yi-Yi Shi,Jie-Jie Cai,Song-Zan Qian,Rui Zheng

doi:10.1186/s12888-021-03275-2

Abstract

BackgroundThe association between triglyceride glucose (TyG) index and depression is unclear. We conducted this analysis to explore whether higher TyG index is associated with a higher odd of depression.MethodsThis was an observational study using data from the National Health and Nutrition Examination Survey (2005–2018), a cross-sectional and nationally representative database. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). TyG index was calculated based on the equation as follows: ln [triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2], and participants were divided into quartiles based on TyG index. Weighted multivariable logistic regression models were used to explore the relationship between the TyG index and depression.ResultsA total of 13,350 patients were included, involving 1001 (7.50%) individuals with depression. Higher TyG index is significantly associated with elevated depressive symptoms in U.S. adults. Multivariate-adjusted HRs for patients in the TyG index 4th quartile were higher for depression (OR = 1.46; 95% confidence interval (CI) 1.30, 1.64) compared with the 1st quartile of TyG index. Similar results were seen in men and women, across age groups, and baseline comorbidities.ConclusionIn this large cross-sectional study, our result suggests that population with higher TyG index are significantly more likely to have depressive symptoms in U.S. adults.

Highlights

Depression is a common mental health issue, clinically characterized by significant and persistent low mood symptoms, linked with considerably diminished rolefunctioning and quality of life, and with high risk of medical comorbidity and mortality [1]
The purpose of this study is to explore the relationship between triglyceride glucose (TyG) index and depression in a large, nationally-representative sample of adults living in the United States
The TyG index across quartiles was positively associated with age, Body Mass Index (BMI), current smoking, alcohol consumption, household income high prevalence of diabetes, congestive heart failure, coronary heart disease, liver condition, cancer or malignancy

Summary

Introduction

Depression is a common mental health issue, clinically characterized by significant and persistent low mood symptoms, linked with considerably diminished rolefunctioning and quality of life, and with high risk of medical comorbidity and mortality [1]. Some large population of observational studies found that diabetes was related to depression caused by insulin resistance [10,11,12]. The triglyceride-glucose (TyG) index is a new indicator of insulin resistance in recent years. Studies show that TyG index is related to disease prognosis, cardiovascular disease, dementia [12, 13]. The purpose of this study is to explore the relationship between TyG index and depression in a large, nationally-representative sample of adults living in the United States. The association between triglyceride glucose (TyG) index and depression is unclear. We conducted this analysis to explore whether higher TyG index is associated with a higher odd of depression

Objectives

Methods

Results