Abstract
(Can J Anaesth. 2017;64(8):820–827) Despite the use of prophylactic agents like oxytocin, the rise in postpartum hemorrhage (PPH) between 2003 and 2010 has been attributed to postpartum uterine atony. Oxytocin reduces PPH by up to 60% when used during the third stage of labor. However, oxytocin is associated with an increased risk of PPH secondary to uterine atony when used for labor augmentation that results in prolonged infusions or high doses. Myometrial oxytocin receptors (OTRs) may be less responsive to oxytocin administered to prevent PPH because the OTRs have become desensitized when exposed to oxytocin during labor augmentation. It is unclear if OTRs can become resensitized after a cessation of oxytocin. This study aimed to assess the association between blood loss and the interval of time between discontinuing oxytocin and cesarean delivery (CD).
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