Abstract
The association between the rs6495309 polymorphism in CHRNA3 gene and lung cancer risk has been studied in Chinese by several number case-control control studies with small number of cases and controls, and these studies might be underpowered to reveal the true association. Thus we sought to investigate the association with the risk of lung cancer by performing a comprehensive meta-analysis on the polymorphism. Five case-control studies were extracted from 3 articles on the polymorphism involving 4608 lung cancer cases and 4617 controls. The results of meta-analysis showed that significant increased risk were found for the polymorphism with the risk of lung cancer in Chinese: OR = 1.47, 95%CI = 1.33–1.63, P < 0.00001 for CC + TC vs. TT; OR = 1.24, 95%CI = 1.07–1.44, P = 0.005 for CC vs. TT + TC; OR = 1.62, 95%CI = 1.32–2.00, P < 0.00001 for CC vs. TT; OR = 1.42, 95%CI = 1.26–1.61, P < 0.00001 for CT vs. TT; OR = 1.42, 95%CI = 1.26–1.61, P < 0.00001. No significant publication bias was found for the five genetic models. Our findings demonstrated that CHRNA3 gene rs6495309 polymorphism might be a risk factor for the development of lung cancer in Chinese.
Highlights
The association between the rs6495309 polymorphism in CHRNA3 gene and lung cancer risk in Chinese: a meta-analysis
A total of 5 articles that investigated the association between the rs6495309 polymorphism in CHRNA3 gene and the risk of lung cancer in Chinese were left for data extraction
We found a significant association between CHRNA3 rs6495309 polymorphism and lung cancer risk for Chinese
Summary
The association between the rs6495309 polymorphism in CHRNA3 gene and lung cancer risk in Chinese: a meta-analysis. Many individual studies have set out to determine whether there is an association between genetic polymorphisms and lung cancer susceptibility, such as CHRNA3 polymorphisms[8,9]. Several polymorphisms in the gene have been identified, such as the rs6495309, rs8034191 and rs105173010–12 Among these polymorphisms, the rs6495309 is one of the widely studied polymorphisms for Chinese, and several studies have performed to study the association between the polymorphism with the risk of lung cancer in Chinese[13,14,15]. In order to get more precision results for the polymorphism and the risk of lung cancer in Chinese, we carried out a meta-analysis including all eligible studies published to date to systematically and comprehensively estimate the association the polymorphism and susceptibility to lung cancer among Chinese population. This is, to our knowledge, the first meta-analysis that investigated the association between the CHRNA3 polymorphisms and lung cancer risk for Chinese
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
