Abstract
The unleased proliferation of lymphoid progenitor cells could result in Acute lymphoblastic leukemia (ALL). The early diagnosis of this malignancy, with high prevalence in children and poor prognosis in adults, has remained a big challenge. Single Nucleotide Polymorphisms (SNPs) could be studied as potent genetic factors to be used as the diagnosis and prognosis biomarkers. Although some SNPs with significant association with the risk of ALL have been reported, more studies are needed to improve the list of these biomarkers to better predict the risk of ALL cancer. In this study, we selected and genotyped eight SNPs in ALL patients and healthy controls using the tetra-primer ARMS PCR method. The outcomes significantly revealed that the presence of different alleles at the SNPs positions could manipulate the risk of ALL incidence. These SNPs include rs10757278, rs1800472, rs12430881, rs35958982, rs1946518, rs4073, rs3813865 and rs889312. The data obtained from this work might have implications in clinics.
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