Abstract
Epidemiological studies have demonstrated close associations between SET8 rs16917496 T/C polymorphism and cancer risk, but the results of published studies were not consistent. We therefore performed this meta-analysis to explore the associations between rs16917496 T/C polymorphism and cancer risk. Five online databases were searched. Odds ratios (ORs) with a 95% confidence interval (CI) were calculated to assess the association between rs16917496 T/C polymorphism and cancer risk. In addition, heterogeneity, accumulative, sensitivity analysis, and publication bias were conducted to check the statistical power. Overall, 13 publications involving 5878 subjects were identified according to included criteria. No significant cancer risk was observed in genetic model of SET8 rs16917496 T/C polymorphism in Asian populations (C vs. T: OR = 1.04, 95%CI = 0.88–1.23, P = 0.63%; TC vs. TT: OR = 1.17, 95%CI = 0.96–1.24, P = 0.11%; CC vs. TT: OR = 0.90, 95%CI = 0.60–1.37, P = 0.63; TC+CC vs. TT: OR = 1.11, 95%CI = 0.90–1.38, P = 0.33; CC vs. TT+TC: OR = 0.92, 95%CI = 0.65–1.30, P = 0.63). Furthermore, similar associations were found in the subgroup analysis of race diversity, control design, genotyping methods, and different cancer types. In summary, our meta-analysis indicated that the SET8 rs16917496 T/C polymorphism may not play a critical role in cancer development in Asian populations.
Highlights
Cancer is one of the most common causes of death, second only to cardiovascular disease [1]
Studies were selected according to the following criteria: (1) they should be case–control studies that investigated the association between SET domain-containing protein 8 (SET8) rs16917496 T/C polymorphism and cancer risk; (2) studies should provide sufficient data on genotype distribution which could be used to evaluate odds ratios (ORs) and 95% confidence intervals (CIs); (3) studies were published either in English or Chinese; and (4) publications included the largest or most recent sample data available when overlapping or duplicate data were published on the same item
The improvement in cancer detection and treatments has resulted in decreased incidence and mortality rates of several cancer types
Summary
Cancer is one of the most common causes of death, second only to cardiovascular disease [1]. Radiotherapy, and chemotherapy are the most important cancer treatments [3,4,5]. These methods induce harmful side effects in patients, and the resulting damage to the treated tissues and organs causes considerable physical dysfunction as well as a reduction in quality of life. SET8 could be involved in multiple biological processes, such as gene transcriptional regulation, genome replication genomic stability, and cell cycle management c 2018 The Author(s)
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