Abstract
Background: The aim of this retrospective study was to analyze the association between prolactin (PRL) and metabolic parameters in infertile patients with polycystic ovary syndrome (PCOS).Methods: A total of 2,052 patients with PCOS and 9,696 patients with tubal infertility (non-PCOS) undergoing in vitro fertilization and embryo transfer (IVF-ET) at the reproductive medicine center of the first affiliated hospital of Wenzhou Medical University from January 2007 to July 2017 were enrolled in this study. Serum PRL, basic endocrine hormones, fasting plasma lipid, fasting plasma glucose (FPG), liver function, thyroid hormone and other parameters were measured and analyzed.Result: PRL levels were significantly lower in PCOS patients than controls over all age groups (p < 0.05). In the PCOS patients, serum PRL was significantly and positively correlated with FPG, serum TSH and serum FT4, and significantly and negatively correlated with LH, LH/FSH, TC, TG, LDL-C, AST, ALT, γ-GGT, FT3, and FT3/FT4 (p < 0.05 or 0.01). After adjusted for age and body mass index (BMI), serum PRL was positively correlated with FPG, TSH, and FT4, and negatively correlated with LH and LH/FSH.Conclusion: Low serum PRL may be an important cause of metabolic risk in infertile patients with PCOS.
Highlights
The aim of this retrospective study was to analyze the association between prolactin (PRL) and metabolic parameters in infertile patients with polycystic ovary syndrome (PCOS)
After adjusted for body mass index (BMI), the levels of PRL and Follicle stimulating hormone (FSH) were significantly lower, while systolic blood pressure (SBP), diastolic blood pressure (DBP), Luteinizing hormone (LH), LH/FSH, testosterone (T), TG, Total cholesterol (TC), Low density lipoprotein cholesterol (LDL-C), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), γ -GGT, Alkaline phosphatase (ALP), and uric acid were significantly higher in PCOS patients than in non- PCOS patients group (Table 1; p < 0.05 or p < 0.01) in all age groups
The results showed that in lower PRL quartile, the age, BMI, LH, LH/FSH, TG, TC, LDL-C, AST, ALT, y-GGT, Free triiodothyronine (FT3), and FT3/Free thyroxine (FT4) were higher, while Fasting plasma glucose (FPG), Thyroid stimulating hormone (TSH), and FT4 were lower (p < 0.05 or p < 0.01)
Summary
The aim of this retrospective study was to analyze the association between prolactin (PRL) and metabolic parameters in infertile patients with polycystic ovary syndrome (PCOS). Studies have demonstrated that prolactin (PRL) has more than 300 other functions in addition to regulating the development of breast and lactation [1,2,3,4,5]. The regulatory roles of PRL in metabolism has been a focus of research in recent years. The role of PRL in promoting insulin secretion in islets is welldemonstrated [8]. PRL stimulates the proliferation and survival of islet β cells, improves the quality of β cells and enhances the secretion of insulin and sensitizes the liver to insulin [9,10,11]. Study has shown that PRL can affect metabolism homeostasis, glucose and lipid storage by regulating key enzymes and transporters related to glucose and lipid metabolism in the target organs [12]
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