Abstract
BackgroundDetermining the modifiable risk factors for postoperative complications is particularly significant in patients undergoing colorectal surgery since those are associated with worse long-term outcomes.MethodsConsecutive newly diagnosed 104 colorectal cancer patients were prospectively included in this single-center observational study. Preoperative serum 25-OH vitamin D levels were measured and analyzed for infectious and postoperative complications.ResultsSerum 25-OH vitamin D levels were found to be < 20 ng/ml in 74 patients (71.2%) and ≥ 20 ng/ml in 30 patients (28.8%); and the mean serum 25-OH vitamin D level was 15.95 (± 9.08) ng/ml. In patients with surgical site infection and infectious complications, 25-OH vitamin D levels were significantly lower than patients without complications (p = 0.036 and p = 0.026). However, no significant difference was demonstrated in 25-OH vitamin D levels according to overall postoperative complications.ConclusionsOur results suggest that vitamin D levels might be a potential risk factor for infectious complications in patients undergoing colorectal cancer surgery.
Highlights
Determining the modifiable risk factors for postoperative complications is significant in patients undergoing colorectal surgery since those are associated with worse long-term outcomes
25-hydroxy (OH) vitamin D levels have been inversely related to colorectal cancer risk by causing adenoma formation in colon epithelium [13,14,15,16]. 25-OH vitamin D levels have been associated with long-term survival and increased response to oncological treatment; its effect on postoperative complication (PoC) has not been thoroughly investigated [17, 18]
The present study aimed to evaluate the association between serum 25-OH vitamin D levels and PoC and observe its effect on short-term outcomes in colorectal cancer patients
Summary
Determining the modifiable risk factors for postoperative complications is significant in patients undergoing colorectal surgery since those are associated with worse long-term outcomes. Despite improvements in postoperative care, the rate of postoperative complication (PoC) is changed between 19 and 30% in patients undergoing elective colorectal surgery [2]. 25-hydroxy (OH) vitamin D levels have been inversely related to colorectal cancer risk by causing adenoma formation in colon epithelium [13,14,15,16]. 25-OH vitamin D levels have been associated with long-term survival and increased response to oncological treatment; its effect on PoC has not been thoroughly investigated [17, 18]. The present study aimed to evaluate the association between serum 25-OH vitamin D levels and PoC and observe its effect on short-term outcomes in colorectal cancer patients 25-hydroxy (OH) vitamin D levels have been inversely related to colorectal cancer risk by causing adenoma formation in colon epithelium [13,14,15,16]. 25-OH vitamin D levels have been associated with long-term survival and increased response to oncological treatment; its effect on PoC has not been thoroughly investigated [17, 18].
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