Abstract
BackgroundDiet, one of the components of lifestyle, has been believed to have associations with erectile dysfunction (ED). However, whether there is an association between plant-based diet and ED is remains to be explored. Thus, we conducted the nested case-control study to investigate the relationship between the plant-based diet and ED in China.ResultsED group (92 subjeczts) and ED free group (92 subjects) were similar in terms of basic features (P > 0.05), except for lifestyle (P < 0.05). The plant-diet index (PDI) and healthy plant-diet index (hPDI) in the ED group were significantly lower than those in the control group (P < 0.001). Adjusted multivariate analysis indicated that the presence of ED was negatively associated with nitric oxide levels, PDI, and hPDI (all P < 0.05), and was positively related to body mass index, metabolic syndrome, and E-selectin levels. Furthermore, both the PDI and hPDI increased significantly as the International Index of Erectile Function (IIEF-5) scores increased within the ED group (P < 0.05). Multi-model multivariate analysis indicated the robustness of results.ConclusionsMore plant-based diet intake was associated with a reduced presence of ED and less severe ED in China. Committing to plant-based diet can be encouraged for many health benefits and to lower ED burden. Further well-designed studies are warranted to validate our findings.
Highlights
Diet, one of the components of lifestyle, has been believed to have associations with erectile dysfunction (ED)
The results of univariate logistic analysis (UVA) showed that the presence of ED was significantly associated with Body mass index (BMI), metabolic syndrome (MetS), nitric oxide (NO) and E-selectin levels, plant-diet index (PDI), and healthy plant-diet index (hPDI), but not TT levels (P = 0.135)
Results from multivariate logistic analysis (MVA) indicated that both the PDI and hPDI increased significantly as the Index of Erectile Function-5 (IIEF-5) scores increased within the ED group (Fig. 2 and Table 4)
Summary
One of the components of lifestyle, has been believed to have associations with erectile dysfunction (ED). Diet modification, proved by several well-designed studies, is considered as a potentially important method for cancer prevention and chronic non-communicable diseases control [1,2,3]. In light of these findings, participation in diet modification, especially the plant-based diet has grown swiftly in recent years. It was indicated that such a diet could reduce the incidence of metabolic syndrome (MetS), heart disease, cancer, and even mortality [6,7,8]. It was demonstrated that a suitable reduction of animal-based diet and a more sustainable plant-based diet pattern reduced about 70% of the greenhouse gas emissions [9]
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