Abstract
ObjectivesInsulin resistance (IR) has been shown to play important role in the pathogenesis of type 2 diabetes mellitus (T2DM). There is an intricate interplay between IR, dyslipidemia, and serum uric acid (SUA) in people with and without diabetes. Physical activity has a positive impact on insulin sensitivity in insulin-resistant populations. However, the effect of different intensities of physical activity on insulin levels under different lipid indices and SUA levels is unclear.MethodsTo explore the association between physical activity and insulin, we enrolled 12,982 participants aged above 18 years from the National Health and Nutrition Examination Survey (NHANES) conducted between 2009 and 2018. Next, we conducted multivariate logistic regression analyses, generated fitted smoothing curves, and visualized the data using generalized additive models.ResultsIncreased intensities of physical activity can significantly reduce insulin levels. The association between physical activity and insulin persisted even after adjusting for confounding factors, with β value (95% CI) = −17.10 (−21.64, −12.56) in moderate group, β value (95% CI) = −28.60 (−33.08, −24.11) in high group, respectively. High-intensity physical activity significantly lowered insulin levels in the lower and higher SUA tertiles, and three tertiles of LDL-c, HDL-c, and TG. Moreover, the link between physical activity and insulin was stronger in male individuals.ConclusionThis study shows that physical activity can significantly lower insulin levels, and high-intensity physical activity still has additional potential benefits for insulin levels, even in the condition of dyslipidemia and hyperuricemia.
Highlights
Insulin resistance (IR) is defined as an impaired biologic response to glucose disposal and insulin stimulation of target tissues, leading to a compensatory increase in beta-cell insulin production and hyperinsulinemia
Results showed that the mean values of HbA1c, glucose, body mass index (BMI), waist circumference (WC), TG, creatinine, insulin, BUN, and systolic blood pressure (SBP) were significantly lower in the high-intensity PA group than in the other two groups
The mean values of high-density lipoprotein cholesterol (HDL-c), AST, ALT, and diastolic blood pressure (DBP) levels were significantly higher in the high-intensity PA group than in the other two groups
Summary
Insulin resistance (IR) is defined as an impaired biologic response to glucose disposal and insulin stimulation of target tissues (mainly the liver, muscle, and adipose tissue), leading to a compensatory increase in beta-cell insulin production and hyperinsulinemia. IR can result in a series of metabolic consequences, such as dyslipidemia, hyperglycemia, visceral adiposity, Physical Activity and Insulin hyperuricemia, hypertension, endothelial dysfunction, a prothrombotic state, and elevated inflammatory response (Freeman and Pennings, 2021). Barnard et al (1988) fed mice a high-fat sucrose diet for a few weeks and found that they developed skeletal muscle insulin resistance and hyperinsulinemia before mice developed hypertriglyceridemia, and hypertension, which resulted in MS. Improving insulin sensitivity is an important part of preventing insulin resistance, diabetes, and CVD
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
