The Association between Parathyroid Hormone and Preterm Labor

Abstract

Abstract Background Preterm labor represents the main cause of both neonatal mortality and the childhood mortality as it accounts for (35% of 2.8 million neonatal deaths) and (17% of 6.3 million childhood deaths) worldwide. Parathyroid hormone regulates feto-placental mineral homeostasis and stimulates placental calcium transfer. Myometrial activity is directly related to cytoplasmic free calcium, and reduced calcium concentrations inhibit contractions. Aim of the Work We aim to explore the possible association between PTH, calcium, magnesium, phosphorus & albumin levels and preterm labor. Thus, it might be used as a predictor to help prophylaxis, early diagnosis or add another diagnostic tool for preterm labor and further management. Patients and Methods At Ain Shams University Maternity Hospital we conducted a case control on one hundred pregnant women who were recruited from the outpatient clinic and labor ward assessed for eligibility and were enrolled in this study and classified into two groups. Group A: Cases: 50 women who were having established preterm labor and Group B: Controls: 50 matched pregnant women with gestational age (28-36 weeks). Results Mean parathyroid hormone in preterm in labor group was 42.13 while in other preterm not in labor was 50.77 and mean albumin in preterm in labor group 4.02 was while it 4.36 was in the other group so the results shows that there is no statistically-significant difference between the two studied groups regarding the laboratory data except a very small variability between the mean of albumin that can't make any difference to our conclusion. Conclusion We found that there is no obvious association between parathyroid hormone and preterm labor.