The Association Between Myoglobin, Troponin I, Hfabp and Nt-Probnp Levels with Acute Myocardial Infarction in Patients with Acute Coronary Syndrome

Abstract

Introduction: Myocardial infarction is one of the five major manifestations of coronary heart disease. Myoglobin heart markers, Isoenzyme Creatine Kinase-MB (CK-MB), cardiac Troponin I (cTnI) or Troponin T (cTnT), Heart type fatty acid-binding protein (HFABP) and NT-proBNPare currently used in assisting the diagnosis of acute myocardial infarction. The study aimed to analyze the association of cardiac marker examination results of myoglobin, cTnI, HFABP and NT-proBNP with AMIoccurrence on examination I and examination II. Method: This study enrolled33 patients in Installation of Emergency Carewith suspected acute coronary syndrome, from March to August 2013. Serum samples were taken including cTnT, myoglobin, cTnI, HFABP and NT-proBNP. Then, it was further analyzed. Results: There was an association between myoglobin, cTnI, HFABP, and NT-proBNP with AMI events. Myoglobin and HFABP wereearly markers for the diagnosis of AMI, the mean levels of both markers was higher at the first examination (<1 hour admitted patients) when compared with 6 hours later after being tested. Essentially, the diagnostic value of both did not differ, only HFABP was more specific than myoglobin. Troponin I showed to be the best choice in the diagnosis of AMI because of the high sensitivity and specificity. Conclusion: An association between myoglobin, cTnI, HFABP, and NT-proBNP with AMI events was found. Myoglobin, cTnI, HFABP can be used in diagnosing AMI patients, whereas NT-proBNP is not recommended for the diagnosis of AMI due to its low specificity.