Abstract
Objectives:We aimed to investigate whether Monocyte-to-HDL ratio (MHR) had an association with albuminuria in patients with diabetic nephropathy (DN).Methods:Diabetic patients, who had admitted to the outpatient clinic of general internal disease department between September 2017 - February 2018 and had their spot urinary albumin/creatinine ratio measured, were examined retrospectively. Patients were separated based on the presence of DN. Patients with DN were grouped as Stage-I, Stage-II and Stage-III chronic kidney disease (CKD). Groups were compared in terms of MHR. The presence of a correlation between MHR and albuminuria was investigated.Results:MHR was found to be higher in the DN (n=85) group compared to Non- DN group. (16.2±5.5 vs. 14.3±4, p=0.037) And there was no significant difference in Stage-I, Stage-II and Stage-III CKD groups in terms of MHR. (15.2± 3.4, 16.1±6.0, 17.1±6.0, p=0.485). No significant correlation was found between MHR and albuminuria in DN and non-DN groups (p=0.634, r=0.052; p=0.553, r=-0.059).Conclusions:DN group had higher MHR than non-nephropathy group, whereas, there was no correlation between albuminuria and MHR.
Highlights
Diabetic Nephropathy (DN) is the most frequent cause leading to renal failure.[1]
Decreased serum highdensity lipoprotein (HDL) concentration and elevated monocyte count in the circulation have been shown in patients with chronic kidney
HDL ratio & albuminuria in diabetic nephropathy was determined to be significantly higher in DN group than the non-DN group (Fig.1)
Summary
Diabetic Nephropathy (DN) is the most frequent cause leading to renal failure.[1] Microalbuminuria is the earliest finding of DN and is an indicator for. Correspondence: November 4, 2020 March 13, 2021 March 20, 2021 cardiovascular mortality and morbidity in diabetic patients. Hyperglycaemia, polyols, advanced glycosylation end products and ischemia are effective in the pathogenesis of DN.[2] The increased formation of advanced glycation end products leads to microvascular and macrovascular complications by causing endothelium and monocyte activation via pro-inflammatory effect. Recent studies have reported that monocyte/highdensity lipoprotein (HDL) ratio (MHR) can be an indicator for inflammation and oxidative stress and that it can be used for cardiovascular diseases. Decreased serum HDL concentration and elevated monocyte count in the circulation have been shown in patients with chronic kidney
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